| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/300 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | HC7-I |
| WB Predicted band size | 23 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human PSMB2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于PSMB2抗体的3篇参考文献示例(内容为模拟虚构，仅供参考)：
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1. **文献名称**: "PSMB2 overexpression promotes tumor progression in hepatocellular carcinoma"
**作者**: Li X, et al.
**摘要**: 研究通过免疫组化(使用PSMB2抗体)发现PSMB2在肝癌组织中高表达，且与患者预后不良相关，机制涉及蛋白酶体活性调控和NF-κB信号通路激活。
2. **文献名称**: "Proteasome subunit PSMB2 as a potential biomarker in colorectal cancer"
**作者**: Wang Y, et al.
**摘要**: 利用Western blot和免疫荧光(PSMB2抗体)分析结直肠癌样本，表明PSMB2表达升高与化疗耐药性相关，提示其可作为治疗靶点或预后标志物。
3. **文献名称**: "Functional characterization of PSMB2 in cellular oxidative stress response"
**作者**: Kim S, et al.
**摘要**: 通过敲低和抗体介导的蛋白检测，证明PSMB2通过调控20S蛋白酶体活性影响细胞氧化应激应答，为神经退行性疾病研究提供新方向。
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注：以上文献为示例，实际引用需通过PubMed或学术数据库检索真实研究。
The PSMB2 (Proteasome 20S Subunit Beta 2) antibody is a research tool used to detect and study the PSMB2 protein, a critical component of the 20S core proteasome complex. The proteasome is a multi-subunit protease responsible for degrading ubiquitinated proteins, a process essential for maintaining cellular homeostasis, regulating cell cycle progression, and managing stress responses. PSMB2. as part of the β-subunit family, contributes to the proteolytic activity of the 20S core, which is involved in the ATP-independent degradation of misfolded or damaged proteins.
Antibodies targeting PSMB2 enable researchers to investigate its expression, localization, and function in various biological contexts. These antibodies are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to assess protein levels in tissues or cultured cells. Dysregulation of proteasome activity, including PSMB2 expression, has been linked to diseases such as cancer, neurodegenerative disorders, and autoimmune conditions. For instance, altered proteasome function may promote tumor survival or contribute to the accumulation of toxic protein aggregates in Alzheimer's or Parkinson's disease.
Additionally, PSMB2 antibodies aid in studying the efficacy of proteasome inhibitors, a class of anticancer drugs. Understanding PSMB2's role in proteostasis provides insights into cellular stress adaptation and potential therapeutic targets for proteasome-related pathologies.
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