Rabbit Polyclonal PPM1B Antibody

The PPM1B antibody is a crucial tool in studying the protein phosphatase, Mg²⁺/Mn²⁺-dependent 1B (PPM1B), a serine/threonine phosphatase belonging to the PP2C family. PPM1B plays a regulatory role in diverse cellular processes, including stress responses, apoptosis, and immune signaling. It dephosphorylates key substrates in pathways such as TGF-β, NF-κB, and p53. thereby modulating their activity. For example, PPM1B negatively regulates the TGF-β pathway by dephosphorylating SMAD2/3 and the IKK complex in NF-κB signaling, impacting inflammation and cell survival. Dysregulation of PPM1B has been linked to diseases like cancer, metabolic disorders, and neurodegenerative conditions. The PPM1B antibody enables detection and quantification of this phosphatase in experimental models, aiding research into its physiological and pathological roles. It is widely used in techniques like Western blotting, immunoprecipitation, and immunofluorescence. Commercial PPM1B antibodies are typically validated for specificity using knockout controls or siRNA knockdown. Understanding PPM1B's interactions and mechanisms through antibody-based assays contributes to therapeutic targeting, particularly in diseases involving aberrant phosphorylation-dependent signaling.