| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/300 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | DC44; HCC3; HCBP6; PD03104 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein of human FUNDC2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于FUNDC2抗体的3篇参考文献及其摘要概括：
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1. **文献名称**: *FUNDC2 regulates mitophagy in colorectal cancer by targeting the mitochondrial protein NIX*
**作者**: Li X, Zhang Y, Chen Q, et al.
**摘要**: 该研究探讨了FUNDC2在结直肠癌细胞线粒体自噬中的作用，发现其通过与NIX蛋白互作调控线粒体清除。研究使用特异性FUNDC2抗体进行Western blot和免疫共沉淀实验，证实FUNDC2表达水平与肿瘤进展相关。
2. **文献名称**: *A novel role of FUNDC2 in mitochondrial dynamics and apoptosis*
**作者**: Wang H, Cheng Z, Liu J.
**摘要**: 本文首次报道FUNDC2参与线粒体分裂与融合的动态平衡，并利用FUNDC2抗体进行免疫荧光定位，发现其在线粒体损伤时募集至线粒体外膜，调控细胞凋亡。研究提示FUNDC2可能是癌症治疗的潜在靶点。
3. **文献名称**: *Development and validation of a polyclonal antibody against human FUNDC2 for functional studies*
**作者**: Chen L, Xu R, Zhou M.
**摘要**: 该研究详细描述了兔源多克隆FUNDC2抗体的制备与验证，通过ELISA、免疫组化和敲除细胞系验证抗体特异性，并应用于多种癌症组织中FUNDC2蛋白表达谱的分析，为后续功能研究提供工具支持。
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注：上述文献为示例，实际引用时需根据真实发表的论文调整信息。若需具体文献，建议在PubMed或Web of Science以“FUNDC2 antibody”或“FUNDC2 function”为关键词检索。
The FUNDC2 (FUN14 domain-containing 2) antibody is a tool used to detect and study the FUNDC2 protein, a mitochondrial outer membrane protein implicated in cellular stress responses and mitochondrial quality control. First identified in 2008. FUNDC2 contains a conserved FUN14 domain and is structurally related to FUNDC1. a known regulator of hypoxia-induced mitophagy. Unlike FUNDC1. however, FUNDC2’s precise molecular mechanisms remain less defined. Studies suggest it may interact with mitochondrial proteins like MFN2 and participate in mitochondrial dynamics, apoptosis, or metabolic regulation.
Research links FUNDC2 to cancer progression, particularly in lung, colorectal, and hepatocellular carcinomas, where its expression levels correlate with patient prognosis. Antibodies against FUNDC2 (polyclonal or monoclonal, often raised in rabbits or mice) enable applications such as Western blotting, immunofluorescence, and immunohistochemistry, aiding in exploring its localization, expression patterns, and interactions.
Despite its potential role in mitochondrial stress adaptation and disease, FUNDC2 remains understudied compared to other mitochondrial proteins. Discrepancies in reported functions highlight the need for further validation using specific antibodies. Current studies focus on clarifying its contributions to mitochondrial homeostasis, cancer biology, and therapeutic targeting. The FUNDC2 antibody thus serves as a critical reagent for unraveling its biological significance and translational relevance.
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