Rabbit Polyclonal TUBD1 Antibody

The TUBD1 antibody targets tubulin delta-1 (TUBD1), a member of the tubulin superfamily involved in microtubule formation and cellular structural organization. TUBD1 is a less-characterized delta-tubulin isoform, primarily studied for its role in centriole and basal body assembly, which are critical for cilia formation and mitotic spindle organization. Unlike alpha- and beta-tubulins, delta-tubulins are non-polymerizing and function as regulatory components in microtubule-related processes. TUBD1 antibodies are essential tools for investigating centriolar biology, ciliopathies, and cell cycle regulation. They are commonly used in immunofluorescence, Western blotting, and immunohistochemistry to localize TUBD1 in cellular structures or assess its expression levels in pathological conditions. Research suggests TUBD1 dysfunction may contribute to cilia-associated disorders, such as retinal degeneration or developmental defects, making its antibody valuable for diagnostic or mechanistic studies. Commercial TUBD1 antibodies are typically raised in hosts like rabbits or mice, validated for specificity against recombinant or endogenous proteins. Recent studies also explore its potential role in cancer, given the link between centrosome abnormalities and genomic instability. However, TUBD1's full functional scope remains under investigation, necessitating further research to clarify its interactions and regulatory pathways.