| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/150-1/300 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| WB Predicted band size | 69 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human KLC2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于KLC2抗体的3篇示例参考文献(注：以下内容为虚构示例，仅供参考格式及内容框架，实际文献需通过学术数据库检索获取)：
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1. **文献名称**：KLC2 Overexpression Promotes Tumor Invasion in Breast Cancer via Dysregulation of Microtubule Dynamics
**作者**：Baranwal, S. et al.
**摘要**：本研究通过免疫组化及Western blot分析，发现KLC2在乳腺癌组织中显著高表达，并与患者预后不良相关。实验表明，KLC2抗体敲低后，癌细胞迁移能力下降，提示其通过调控微管稳定性影响肿瘤侵袭。
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2. **文献名称**：KLC2 Mediates Axonal Transport of Mitochondria in Neuronal Cells
**作者**：Smith, J.R. & Nakamura, T.
**摘要**：利用KLC2特异性抗体进行共沉淀实验，证实KLC2与线粒体膜蛋白TOM20存在相互作用。研究揭示KLC2在神经元轴突中线粒体定向运输的关键作用，缺失会导致能量代谢障碍。
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3. **文献名称**：KLC2 Antibody Reveals Its Role in Viral Infection Trafficking
**作者**：Li, X. et al.
**摘要**：通过KLC2抗体阻断实验，发现宿主细胞中KLC2与某病毒衣壳蛋白结合，促进病毒颗粒的内吞运输。该研究为抗病毒靶点开发提供了新思路。
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如需真实文献，建议在PubMed或Google Scholar中检索关键词“KLC2 antibody”或“Kinesin Light Chain 2”，并筛选应用该抗体的功能研究论文。
**Background of KLC2 Antibody**
The KLC2 (kinesin light chain 2) antibody is a research tool designed to detect and study the KLC2 protein, a component of the kinesin-1 motor complex. Kinesins are microtubule-dependent motor proteins critical for intracellular transport, facilitating the movement of cargoes like organelles, vesicles, and protein complexes along microtubules. KLC2. one of several kinesin light chain isoforms, plays a role in binding cargoes and regulating the activity of the kinesin heavy chain (KHC).
KLC2 is particularly studied in neuronal and non-neuronal cells for its involvement in axonal transport, cell division, and maintaining cellular architecture. Dysregulation of KLC2 has been linked to neurodegenerative diseases (e.g., Alzheimer’s, Huntington’s) and cancer, where altered intracellular transport may contribute to disease progression.
Antibodies targeting KLC2 enable researchers to investigate its expression, localization, and interactions via techniques like Western blotting, immunofluorescence, and immunoprecipitation. These studies help elucidate KLC2’s functional roles and mechanisms in health and disease. Commercial KLC2 antibodies are typically raised in hosts like rabbits or mice, with specificity validated using knockout controls or siRNA-mediated depletion.
Overall, the KLC2 antibody serves as a vital reagent in exploring the molecular basis of intracellular transport and its pathological disruptions.
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