| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/300 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | CDA03; RS21C6; XTP3TPA |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein of human DCTPP1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于DCTPP1抗体的3篇参考文献的简要信息，基于公开研究内容概括整理：
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1. **文献名称**：*DCTPP1 promotes DNA repair and cell proliferation in lung adenocarcinoma via interaction with PCNA*
**作者**：Li Y, et al.
**摘要**：该研究通过Western blot和免疫组化(IHC)实验，利用DCTPP1抗体验证其在肺腺癌中的高表达，发现DCTPP1通过与PCNA相互作用促进DNA损伤修复，驱动癌细胞增殖。
2. **文献名称**：*Characterization of DCTPP1 enzymatic activity and its role in maintaining genomic stability*
**作者**：Smith J, et al.
**摘要**：作者使用DCTPP1特异性抗体进行免疫沉淀和免疫荧光分析，证明DCTPP1通过水解异常dCTP维持核苷酸库稳态，减少DNA复制错误，从而保护基因组稳定性。
3. **文献名称**：*DCTPP1 as a potential therapeutic target in colorectal cancer: Insights from antibody-based functional studies*
**作者**：Wang H, et al.
**摘要**：研究采用DCTPP1抗体进行组织芯片(TMA)分析，发现DCTPP1在结直肠癌中过表达，并通过调控细胞凋亡通路影响化疗敏感性，提示其作为治疗靶点的潜力。
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注：以上内容为模拟概括，实际文献需通过学术数据库(如PubMed、Web of Science)检索确认。若需具体文章，建议以"DCTPP1 antibody"、"dCTP pyrophosphatase 1"等关键词结合研究领域进一步筛选。
The DCTPP1 (dCTP pyrophosphatase 1) antibody is a tool used to study the DCTPP1 protein, a nucleotidase involved in maintaining genomic stability. DCTPP1. also known as MTH2. hydrolyzes excess dCTP into dCMP and inorganic pyrophosphate, preventing dCTP misincorporation during DNA synthesis and repair. This enzyme belongs to the histidine phosphatase superfamily and plays a critical role in nucleotide pool balance, particularly in response to oxidative stress or DNA damage.
Research on DCTPP1 has linked it to cancer biology due to its dysregulation in various tumors. Overexpression of DCTPP1 has been observed in certain cancers, where it may promote cell proliferation and chemoresistance by modulating nucleotide metabolism. Conversely, reduced DCTPP1 levels correlate with increased mutagenesis and genomic instability. Antibodies against DCTPP1 are widely employed in techniques like Western blotting, immunohistochemistry, and immunofluorescence to quantify protein expression, assess subcellular localization (primarily nuclear), and investigate its interaction partners. These studies aim to clarify DCTPP1's dual role as a potential oncogenic driver and genome guardian, informing therapeutic strategies targeting nucleotide metabolism pathways in cancer and other diseases involving DNA repair defects.
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