Rabbit Polyclonal DNAL1 Antibody

The DNAL1 (Dynein Light Chain 1) antibody is a tool used to study the DNAL1 protein, a component of the cytoplasmic dynein motor complex. Cytoplasmic dyneins are microtubule-associated motor proteins involved in intracellular transport, organelle positioning, and mitosis. DNAL1. a light chain subunit, plays a regulatory role in dynein-mediated processes by facilitating interactions with cargo adaptors or regulatory proteins. It is ubiquitously expressed and critical for neuronal function, ciliary dynamics, and cell division. Dysregulation of dynein complexes, including DNAL1. has been linked to neurodevelopmental disorders, ciliopathies, and cancer. The DNAL1 antibody is commonly employed in techniques like Western blotting, immunofluorescence, and immunoprecipitation to detect protein expression, localization, and molecular interactions in cellular models. Researchers use it to investigate dynein-related mechanisms in cargo trafficking, cilia assembly, or mitotic defects. Commercial DNAL1 antibodies are typically raised in hosts like rabbits or mice, targeting specific epitopes within the protein's conserved regions. Validation steps, such as knockout controls, are essential to confirm specificity, given the structural similarities among dynein light chain family members. Its applications extend to both basic research and clinical studies exploring dynein dysfunction in disease.