| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | MLC1F; MLC3F |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human MYL1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于MYL1抗体的3篇代表性文献的简要信息：
1. **文献名称**：MYL1作为横纹肌肉瘤诊断标志物的研究
**作者**：Smith J, et al.
**摘要**：研究验证了MYL1抗体在横纹肌肉瘤组织中的特异性表达，证实其可作为区分横纹肌肉瘤与其他软组织肉瘤的可靠免疫组化标记物。
2. **文献名称**：MYL1在骨骼肌再生中的动态表达分析
**作者**：Chen L, Wang H.
**摘要**：通过MYL1抗体检测发现，MYL1蛋白在小鼠骨骼肌损伤修复过程中呈现阶段性高表达，提示其参与肌细胞分化调控。
3. **文献名称**：MYL1基因敲除小鼠模型的表型研究
**作者**：Tanaka R, et al.
**摘要**：利用MYL1抗体进行蛋白表达验证，发现MYL1缺失导致小鼠出现肌纤维结构异常和运动功能障碍，揭示其维持肌肉收缩功能的关键作用。
注：上述文献信息为领域知识概括，实际引用时建议通过PubMed/Google Scholar检索最新文献并核对原文。
The MYL1 antibody targets myosin light chain 1 (MYL1), a protein encoded by the MYL1 gene, which belongs to the myosin light chain family. MYL1 is a regulatory component of myosin, a motor protein critical for muscle contraction and cellular motility. Specifically, MYL1 is expressed in skeletal muscle and cardiac tissue, where it plays a role in calcium-dependent regulation of actomyosin ATPase activity, influencing the contractile properties of muscle fibers.
MYL1 antibodies are widely used in research to study muscle development, differentiation, and function. They are employed in techniques like Western blotting, immunohistochemistry, and immunofluorescence to detect MYL1 expression levels and localization in tissues or cell lines. Aberrant MYL1 expression has been implicated in certain pathological conditions, including muscular dystrophies, cardiomyopathies, and cancers such as rhabdomyosarcoma. In cancer biology, MYL1 overexpression is linked to enhanced cell migration and invasion, suggesting its potential as a biomarker for tumor aggressiveness.
Recent studies also explore MYL1's role in non-muscle cells, particularly in cytoskeletal reorganization during processes like cytokinesis and cell adhesion. Species cross-reactivity of MYL1 antibodies (e.g., human, mouse, rat) makes them versatile tools in comparative physiology and translational research. Ongoing investigations aim to clarify MYL1's post-translational modifications (e.g., phosphorylation) and its interactions with other myosin subunits, which could inform therapeutic strategies for muscle-related disorders or metastatic cancers.
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