| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | HT036 |
| WB Predicted band size | 30 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human HYI |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于HYI抗体的假设性参考文献示例(注：HYI抗体相关研究较为有限，以下内容为模拟示例，供参考)：
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1. **标题**: "HYI Antibody Characterization in Plant Glyoxylate Metabolism"
**作者**: Müller et al.
**摘要**: 研究报道了HYI(Hydroxypyruvate isomerase)抗体的制备及其在拟南芥代谢途径中的定位分析，揭示了HYI酶在光呼吸途径中的关键作用。
2. **标题**: "HYI as a Novel Biomarker in Hepatocellular Carcinoma: Diagnostic Potential of HYI-Specific Antibodies"
**作者**: Chen et al.
**摘要**: 通过HYI抗体检测肝癌患者血清中HYI蛋白的异常表达，提示其可能作为早期肝癌诊断的生物标志物，并探讨了其与肿瘤代谢重编程的关联。
3. **标题**: "Structural Insights into HYI Enzyme via Monoclonal Antibody Binding"
**作者**: Sato et al.
**摘要**: 利用单克隆抗体解析HYI蛋白的三维结构，揭示了其催化活性位点，为设计代谢疾病(如高草酸尿症)的抑制剂提供了依据。
4. **标题**: "HYI Antibody Cross-Reactivity in Microbial and Human Proteomes"
**作者**: Gupta et al.
**摘要**: 评估了HYI抗体在微生物与人类蛋白组的交叉反应性，强调其在研究宿主-病原体相互作用中的潜在应用及实验设计中的注意事项。
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**备注**：若HYI指代其他特定抗原(如H-Y抗原)，建议核实术语准确性并调整关键词检索。实际文献需通过学术数据库(PubMed、Web of Science)查询。
HYI antibody is a research tool designed to target hydroxypyruvate isomerase (HYI), an enzyme encoded by the *HYI* gene in humans. HYI plays a critical role in the pentose phosphate pathway, particularly in catalyzing the isomerization of hydroxypyruvate to tartronate semialdehyde, a step essential for carbohydrate metabolism and cellular redox balance. Dysregulation of HYI has been implicated in metabolic disorders and rare genetic conditions like primary hyperoxaluria type 3. where mutations in *HYI* disrupt glyoxylate metabolism, leading to excessive oxalate production and kidney damage.
Developed primarily in model organisms like rabbits or mice, HYI antibodies are polyclonal or monoclonal reagents validated for applications such as Western blotting, immunohistochemistry, and immunofluorescence. These antibodies enable researchers to study HYI expression patterns, localization, and abundance across tissues, providing insights into its physiological and pathological roles. Recent studies also explore HYI's potential links to cancer metabolism, where altered enzyme activity may influence tumor progression or therapeutic resistance. As a reagent, HYI antibody supports both basic biochemical research and clinical investigations, aiding in biomarker discovery and mechanistic studies of metabolic diseases.
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