| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | CIP; CINAP; AD-004; hCINAP; CGI-137 |
| WB Predicted band size | 20 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human AK6 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于AK6抗体的3篇参考文献及其摘要信息(注：文献为示例性内容，实际引用需核实具体数据库)：
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1. **文献名称**: *AK6 modulates cell cycle progression via its interaction with Aurora kinase A*
**作者**: Zhang Y, et al.
**摘要**: 本研究通过AK6特异性抗体揭示了AK6蛋白在细胞周期调控中的作用，发现其通过与Aurora激酶A互作调控G2/M期转换，抗体在HeLa细胞中的免疫沉淀实验证实了二者的结合。
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2. **文献名称**: *Development of a monoclonal antibody against human AK6 for cancer biomarker screening*
**作者**: Lee S, et al.
**摘要**: 文章报道了一种针对人源AK6的单克隆抗体的开发，该抗体通过ELISA和免疫组化验证，可用于结直肠癌组织样本中AK6表达的定量检测，显示AK6高表达与患者预后不良相关。
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3. **文献名称**: *AK6 deficiency impairs mitochondrial function and promotes cellular senescence*
**作者**: Wang H, et al.
**摘要**: 利用AK6抗体进行蛋白质定位分析，发现AK6缺失导致线粒体能量代谢异常并加速细胞衰老，抗体在免疫荧光实验中证实AK6主要定位于线粒体基质。
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**备注**：以上文献信息为模拟生成，实际研究中建议通过PubMed、Web of Science等平台检索具体论文，并核对作者及摘要准确性。
The AK6 antibody targets adenylate kinase 6 (AK6), a nucleoside monophosphate (NMP) kinase involved in nucleotide metabolism and energy homeostasis. AK6 catalyzes the reversible transfer of phosphate groups between nucleotides, playing a critical role in maintaining cellular energy balance and nucleotide pools. It is primarily localized in the nucleus and cytoplasm, with studies suggesting its involvement in cell proliferation, apoptosis, and DNA repair. Dysregulation of AK6 has been linked to pathological conditions, including cancer, where its overexpression or mutations may influence tumor progression and chemoresistance.
AK6 antibodies are essential tools for investigating the protein's expression, localization, and functional mechanisms. They are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to study AK6's role in cellular processes and disease contexts. Recent research highlights AK6's potential as a biomarker in certain cancers, driving interest in therapeutic targeting. However, the functional complexity of AK6. including its interplay with other kinases and signaling pathways, remains under exploration. Commercial AK6 antibodies are typically validated for specificity across human and model organisms, aiding both basic and translational studies in molecular biology and oncology.
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