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Rabbit Polyclonal TMX3 Antibody

  • 中文名: TMX3抗体
  • 别    名: PDIA13; TXNDC10
货号: IPDX10290
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/50-1/200 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 1/5000-1/10000 Human,Mouse,Rat

产品详情

AliasesPDIA13; TXNDC10
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenFusion protein of human TMX3
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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参考文献

以下是关于TMX3抗体的3篇示例参考文献(注:以下文献信息为示例性内容,具体文献请根据实际研究检索):

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1. **文献名称**:*TMX3 modulates ER stress-induced apoptosis through interaction with Bcl-2 proteins*

**作者**:Matsuo, Y., et al. (2015)

**摘要**:本研究揭示了TMX3(硫氧还蛋白相关跨膜蛋白3)在内质网应激介导的细胞凋亡中的调控作用。通过使用特异性TMX3抗体进行免疫沉淀和免疫荧光实验,发现TMX3通过结合Bcl-2家族蛋白调控线粒体凋亡途径,为癌症治疗提供潜在靶点。

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2. **文献名称**:*TMX3 expression in neurodegenerative disorders: Insights from mouse models*

**作者**:Smith, J.R., et al. (2018)

**摘要**:研究利用TMX3抗体对阿尔茨海默病模型小鼠脑组织进行Western blot和免疫组化分析,发现TMX3在神经元内质网中表达上调,并与tau蛋白异常磷酸化相关,提示其可能参与神经退行性病变的氧化应激调控。

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3. **文献名称**:*Structural characterization of TMX3 and its role in redox signaling*

**作者**:Chen, L., et al. (2020)

**摘要**:通过重组TMX3蛋白及商业化TMX3抗体,本研究解析了TMX3的跨膜结构域及其硫氧还蛋白活性位点的功能,证明其在细胞氧化还原平衡中通过调控PDI(蛋白质二硫键异构酶)活性影响蛋白质折叠。

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4. **文献名称**:*TMX3 antibody-based profiling reveals immune cell-specific expression patterns*

**作者**:Gupta, S., et al. (2022)

**摘要**:利用流式细胞术和高通量单细胞测序结合TMX3抗体,研究发现TMX3在调节T细胞活化及炎症反应中具有独特表达模式,为自身免疫疾病的生物标志物研究提供了新方向。

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如需具体文献,建议通过PubMed或Google Scholar检索关键词“TMX3 antibody”或“Thioredoxin-related transmembrane protein 3”获取最新研究。

背景信息

The TMX3 (Thioredoxin-related transmembrane protein 3) antibody is a tool used to study the TMX3 protein, a member of the thioredoxin (Trx) family. TMX3 is a transmembrane protein localized primarily in the endoplasmic reticulum (ER), characterized by a conserved thioredoxin-like domain containing a CXXC active-site motif. Unlike other thioredoxin family members, TMX3 lacks a canonical ER retrieval signal but retains disulfide isomerase activity, playing roles in oxidative protein folding, quality control, and redox regulation within the ER. It interacts with ER-resident chaperones and participates in processes such as ER-associated degradation (ERAD) and the unfolded protein response (UPR). Research highlights its involvement in cellular stress responses, cancer progression, and neurodegenerative diseases. TMX3 antibodies are widely utilized in techniques like Western blotting, immunofluorescence, and immunohistochemistry to investigate its expression, subcellular localization, and interactions. Studies using these antibodies have revealed TMX3's dysregulation in tumors, where it may influence apoptosis resistance and metastasis, as well as its potential role in modulating ER stress in Alzheimer’s and Parkinson’s diseases. The antibody’s specificity and reliability are critical for elucidating TMX3’s molecular mechanisms and therapeutic relevance.

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