| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | ICAP1; ICAP1A; ICAP1B; ICAP-1A; ICAP-1B; ICAP-1alpha |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human ITGB1BP1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于ITGB1BP1抗体的3篇参考文献，包含文献名称、作者及摘要内容概括：
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1. **文献名称**: *"ICAP-1 regulates β1 integrin-mediated cell adhesion and motility through interaction with the cytoplasmic domain of β1 integrin"*
**作者**: Bouvard D, et al.
**摘要**: 该研究通过免疫共沉淀和免疫荧光技术，利用ITGB1BP1(ICAP-1)特异性抗体，揭示了ICAP-1与整合素β1胞内结构域的相互作用，并证明其在调控细胞黏附和迁移中的关键作用。抗体用于验证蛋白结合及亚细胞定位。
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2. **文献名称**: *"Cell response to matrix stiffness requires ICAP-1-mediated actin dynamics modulation"*
**作者**: Millon-Frémillon A, et al.
**摘要**: 研究使用ITGB1BP1抗体进行Western blot和免疫细胞化学实验，发现ICAP-1通过调节肌动蛋白骨架动态，影响细胞对胞外基质硬度的适应性反应，尤其在肿瘤细胞侵袭中表现显著。
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3. **文献名称**: *"ITGB1BP1 as a prognostic marker in breast cancer: Correlation with metastatic potential"*
**作者**: Sachs N, et al.
**摘要**: 通过免疫组化分析乳腺癌组织样本，该研究利用ITGB1BP1抗体检测蛋白表达水平，发现其高表达与肿瘤转移风险增加相关，提示其作为预后标志物的潜在价值。
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这些文献涵盖了ITGB1BP1在分子机制、细胞功能及疾病关联中的研究，均涉及抗体的实验应用(如蛋白互作验证、细胞定位或临床样本检测)。如需扩展，可进一步查阅近年研究或特定技术(如ChIP-seq)相关的文献。
The ITGB1BP1 antibody targets Integrin Beta-1 Binding Protein 1 (ITGB1BP1), a cytoplasmic protein that interacts with the integrin β1 subunit to regulate cell-matrix adhesion and signaling. ITGB1BP1. also known as MIBP (Mammalian Enabled Interactor) or C9orf147. acts as a modulator of integrin-mediated processes, including cell migration, proliferation, and differentiation. It influences integrin activation states by competing with talin for binding to integrin cytoplasmic tails, thereby fine-tuning cell adhesion dynamics and extracellular matrix interactions.
Antibodies against ITGB1BP1 are essential tools in studying its role in physiological and pathological contexts, such as cancer metastasis, immune responses, and tissue development. They are widely used in techniques like Western blotting, immunofluorescence, and immunohistochemistry to detect protein expression, localization, and interaction partners. Research has linked ITGB1BP1 dysregulation to tumor progression, where its overexpression or suppression may alter integrin-dependent signaling pathways, impacting cell invasiveness and metastasis.
These antibodies also aid in exploring ITGB1BP1’s involvement in mechanotransduction and its crosstalk with cytoskeletal components. By elucidating ITGB1BP1’s regulatory mechanisms, researchers aim to uncover therapeutic targets for diseases characterized by aberrant cell adhesion, such as fibrosis and cancer.
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