| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | GIG4 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human RAB13 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于RAB13抗体的3篇参考文献示例(内容为模拟概括，非真实文献)：
1. **文献名称**：*RAB13 regulates membrane trafficking between TGN and recycling endosomes in polarized epithelial cells*
**作者**：Marzesco AM, et al.
**摘要**：研究利用RAB13抗体进行免疫荧光和免疫印迹分析，揭示了RAB13在极性上皮细胞中调控跨膜蛋白运输的机制，尤其是在紧密连接形成中的作用。
2. **文献名称**：*Role of RAB13 in cancer cell migration and invasion through β1-integrin trafficking*
**作者**：Fukuda M, et al.
**摘要**：通过RAB13抗体的功能阻断实验，发现RAB13通过调控β1-整合素的循环影响乳腺癌细胞的迁移和侵袭能力，提示其作为潜在治疗靶点。
3. **文献名称**：*Antibody-based profiling of RAB13 expression in colorectal cancer tissues*
**作者**：Zhang L, et al.
**摘要**：研究使用特异性RAB13抗体对结直肠癌组织进行免疫组化分析，发现RAB13高表达与肿瘤转移和不良预后显著相关，支持其在癌症进展中的功能。
(注：以上文献信息为模拟生成，实际引用需检索PubMed等数据库获取真实文献。)
Rab13. a member of the Rab GTPase family, plays a critical role in regulating membrane trafficking and cellular compartment organization. It is involved in maintaining cell polarity, junctional assembly, and vesicle transport, particularly in epithelial and endothelial cells. Rab13 cycles between an active GTP-bound state and an inactive GDP-bound state, interacting with effector proteins to mediate intracellular trafficking pathways. Its functions are linked to processes like tight junction dynamics, cell migration, and secretion, making it relevant in cancer metastasis, epithelial barrier integrity, and endocrine signaling.
Rab13 antibodies are essential tools for studying its expression, localization, and activity in these contexts. They enable detection via techniques such as Western blotting, immunofluorescence, and immunohistochemistry, helping researchers map Rab13's distribution in tissues or cultured cells. Specific antibodies can distinguish between GTP- or GDP-bound states, offering insights into its activation status. Some antibodies target unique epitopes to avoid cross-reactivity with other Rab family members.
Dysregulation of Rab13 is implicated in diseases like metastatic cancers, diabetes, and inflammatory bowel disease, where membrane trafficking or cell polarity is disrupted. Rab13 antibodies thus contribute to understanding disease mechanisms and evaluating therapeutic targets. Validation of these antibodies (e.g., knockout controls, functional assays) is crucial to ensure specificity, given the high homology among Rab proteins. Overall, Rab13 antibodies serve as pivotal reagents in cell biology and translational research.
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