| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | SSB2; OBFC2A; SOSS-B2 |
| WB Predicted band size | 22 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human NABP1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于NABP1抗体的参考文献示例(注：部分内容为示例性概括，实际文献可能需要通过学术数据库进一步检索)：
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1. **文献名称**：*NABP1/SSB1 maintains genomic stability through binding and protecting single-stranded DNA*
**作者**：Zhang R. et al.
**摘要**：本研究揭示了NABP1(又称SSB1)作为单链DNA结合蛋白，在DNA损伤修复中的关键作用。通过特异性抗体检测，发现NABP1与RPA蛋白复合物协作，稳定复制叉并促进同源重组修复。抗体应用于免疫沉淀实验，证实其与单链DNA的高亲和力。
2. **文献名称**：*Development and validation of a monoclonal antibody targeting NABP1 for cancer biomarker studies*
**作者**：Lee S. et al.
**摘要**：研究团队开发了一种高特异性NABP1单克隆抗体，并验证其在Western blot和免疫组化中的应用。结果表明，NABP1在多种癌细胞系中高表达，可能与化疗耐药性相关。
3. **文献名称**：*NABP1 deficiency disrupts meiotic progression and impairs fertility in mice*
**作者**：Chen X. et al.
**摘要**：利用NABP1抗体进行免疫荧光定位，发现NABP1在小鼠减数分裂细胞中富集于染色体轴区域。基因敲除导致同源染色体联会异常，提示其在生殖细胞发育中的必要性。
4. **文献名称**：*Prognostic significance of NABP1 overexpression in colorectal cancer*
**作者**：Wang Y. et al.
**摘要**：通过抗体验证，NABP1在结直肠癌组织中表达显著上调，且高表达患者总生存期较短。机制研究表明其可能通过调控DNA修复通路促进肿瘤进展。
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**提示**：以上文献为示例性概括，具体内容需通过PubMed、Google Scholar等平台以关键词“NABP1 antibody”、“SSB1 antibody”或“NABP1 function”检索真实文献。实际研究中，NABP1常与DNA修复、癌症及基因组稳定性相关。
The NABP1 (Nucleic Acid Binding Protein 1) antibody targets a protein critical in maintaining genomic stability. NABP1. also known as SSB1 (Single-Stranded DNA Binding Protein 1), binds transiently to single-stranded DNA (ssDNA) generated during DNA replication, repair, or damage response. It contains OB-fold domains that facilitate ssDNA interaction and collaborates with proteins like RPA and HSP90 to stabilize replication forks or repair intermediates. Dysregulation of NABP1 is linked to genomic instability, cancer progression, and chemoresistance.
Antibodies against NABP1 are essential tools for studying its expression, localization, and function. They enable detection via techniques like Western blot, immunofluorescence, and immunoprecipitation, helping elucidate its role in DNA damage response pathways. Commercial NABP1 antibodies are typically raised in rabbits or mice, validated for specificity in human or model organism samples. Researchers use these antibodies to explore NABP1’s overexpression in certain cancers, its interaction with tumor suppressors (e.g., BRCA1), and its potential as a therapeutic target. Proper validation, including knockout controls, is critical due to cross-reactivity risks with homologous proteins like NABP2/SSB2.
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