| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | rrGTPbp; NY-MEL-1 |
| WB Predicted band size | 24 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human RAB38 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于RAB38抗体的模拟参考文献示例(请注意，以下内容为虚构，建议通过学术数据库查询真实文献)：
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1. **文献名称**: *RAB38 in melanosome biogenesis: Functional characterization and antibody validation*
**作者**: Yasumoto K, et al.
**摘要**: 研究利用RAB38特异性抗体探究其在黑色素细胞中黑色素体形成的作用，发现RAB38通过调控酪氨酸酶运输影响黑色素生成，抗体免疫染色证实其与晚期内体/溶酶体结构的共定位。
2. **文献名称**: *RAB38 mutations in Hermansky-Pudlak syndrome: Antibody-based detection of protein truncation*
**作者**: Cullinane AR, et al.
**摘要**: 通过Western blot和免疫荧光技术，使用抗RAB38抗体分析赫尔曼斯基-普德拉克综合征患者的突变体，发现RAB38截短蛋白导致肺泡II型细胞表面活性物质分泌缺陷。
3. **文献名称**: *Development of a monoclonal antibody against RAB38 for lung cancer biomarker studies*
**作者**: Sasaki T, et al.
**摘要**: 报道一种新型抗RAB38单克隆抗体的开发，验证其在肺癌组织中的特异性表达，并发现RAB38高表达与肿瘤细胞内囊泡运输异常相关。
4. **文献名称**: *RAB38 regulates cargo sorting in regulated secretory pathways: Insights from siRNA and antibody-based knockdown*
**作者**: Wasmeier C, et al.
**摘要**: 结合siRNA和抗RAB38抗体功能抑制实验，揭示RAB38在内分泌细胞分泌颗粒形成中的作用，证明其通过调控特定GTPase活性影响蛋白分选。
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**注意**：以上文献为示例，实际研究请通过 **PubMed/Google Scholar** 检索关键词(如“RAB38 antibody”、“RAB38 function”)获取真实文献。
The RAB38 antibody is a crucial tool for studying the RAB38 protein, a member of the RAS-associated binding (RAB) GTPase family. RAB38 regulates intracellular vesicular trafficking, particularly in melanosomes, lysosome-related organelles, and specialized secretory pathways. It plays a role in melanin synthesis by influencing melanosome maturation and trafficking of tyrosinase, a key enzyme in melanogenesis. Dysregulation of RAB38 is linked to genetic disorders like Hermansky-Pudlak syndrome (HPS), characterized by oculocutaneous albinism and platelet dysfunction, as well as cancers such as melanoma.
RAB38 antibodies are widely used in research to detect protein expression, localization, and interactions via techniques like Western blotting, immunohistochemistry, and immunofluorescence. These antibodies help elucidate RAB38’s functional roles in cellular processes, including membrane trafficking, autophagy, and cell signaling. Commercial antibodies vary in specificity, targeting different epitopes (e.g., N-terminal or C-terminal regions) across species (human, mouse, rat). Validation through knockout controls or siRNA knockdown is essential to confirm antibody reliability.
Recent studies also explore RAB38’s potential as a therapeutic target or biomarker in cancer and genetic diseases. Its tissue-specific expression in melanocytes, lung, and platelets underscores its diverse physiological relevance, driving ongoing interest in RAB38 antibody development and applications.
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