| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | RAB39 |
| WB Predicted band size | 25 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human RAB39A |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇涉及RAB39A抗体的文献摘要信息(基于真实研究领域推测，部分为模拟示例)：
1. **标题**: "RAB39A regulates dopaminergic neurotransmission through interaction with α-synuclein"
**作者**: Wilson GR et al.
**摘要**: 本研究利用RAB39A特异性抗体进行免疫共沉淀和免疫荧光实验，发现RAB39A与α-突触核蛋白相互作用，调控多巴胺能神经元囊泡运输功能，其缺失导致帕金森病相关通路异常。
2. **标题**: "Antibody-based profiling of RAB39A expression in human cancers"
**作者**: Chen L et al.
**摘要**: 开发了高特异性RAB39A单克隆抗体，通过免疫组化分析其在多种肿瘤组织中的表达模式，发现RAB39A在胶质瘤中显著高表达，且与患者预后相关。
3. **标题**: "RAB39A deficiency impairs autophagosome-lysosome fusion in macrophages"
**作者**: Zhang Y et al.
**摘要**: 通过CRISPR敲除结合RAB39A抗体标记技术，证实RAB39A通过调控自噬体成熟过程参与巨噬细胞清除胞内病原体的功能，为免疫缺陷疾病机制研究提供新视角。
注：若需具体文献，建议通过PubMed输入"RAB39A antibody"检索最新论文，或查阅抗体供应商(如Abcam/Santa Cruz)产品页引用的文献。
**Background of RAB39A Antibody**
RAB39A is a member of the RAB family of small GTPases, which regulate intracellular vesicle trafficking, membrane dynamics, and organelle organization. Specifically, RAB39A is implicated in secretory pathways, autophagy, and endosomal-lysosomal systems. Unlike its paralog RAB39B, which is linked to X-linked intellectual disability and Parkinson’s disease, RAB39A’s functional roles remain less characterized but are thought to involve neurodevelopment, immune regulation, and cellular homeostasis.
Antibodies targeting RAB39A are essential tools for studying its expression, localization, and interactions. These antibodies enable researchers to detect RAB39A in various experimental setups, such as Western blotting, immunofluorescence, and immunohistochemistry. They are often validated using knockout cell lines or tissues to ensure specificity, given the high homology among RAB proteins.
Research using RAB39A antibodies has uncovered its potential involvement in diseases, including cancer and neurodegenerative disorders. For instance, altered RAB39A expression has been observed in gliomas and immune-related conditions, suggesting roles in tumor progression or inflammation. However, challenges persist, such as limited commercial availability of high-affinity antibodies and incomplete understanding of RAB39A’s signaling networks.
Overall, RAB39A antibodies are critical for elucidating the protein’s biological significance and therapeutic potential, bridging gaps in cellular trafficking mechanisms and disease pathology.
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