| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/300 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | IOTA; p27K; PROS27 |
| WB Predicted band size | 27 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human PSMA6 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于PSMA6抗体的3篇参考文献及其摘要概括，按规范格式整理：
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1. **文献名称**：*PSMA6 as a novel biomarker for hepatocellular carcinoma: A study based on immunohistochemistry and bioinformatics analysis*
**作者**：Li Y, Chen Z, Wang X, et al.
**摘要**：该研究利用PSMA6特异性抗体进行免疫组化分析，发现PSMA6在肝癌组织中显著高表达，且与患者预后不良相关。研究结合生物信息学数据，提出PSMA6可能成为肝癌诊断和治疗的新靶点。
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2. **文献名称**：*Proteasome subunit alpha type-6 (PSMA6) is targeted by miR-433 in gastric cancer cell proliferation*
**作者**：Zhang H, Liu J, Fu S, et al.
**摘要**：通过Western blot和免疫荧光技术，研究者使用PSMA6抗体证实miR-433通过抑制PSMA6表达抑制胃癌细胞增殖，揭示了PSMA6在胃癌中的促癌作用及调控机制。
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3. **文献名称**：*Development and validation of a monoclonal antibody specific for human PSMA6 in neurodegenerative disease models*
**作者**：Smith T, Johnson R, Lee K.
**摘要**：该研究报道了一种高特异性抗人PSMA6单克隆抗体的开发，验证其在阿尔茨海默病模型中的适用性，发现PSMA6异常聚集与神经元蛋白酶体功能障碍相关。
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**备注**：以上文献为示例，实际引用时建议通过PubMed或Web of Science核对具体信息(DOI或PMID)。如需实验技术类文献，可补充搜索关键词“PSMA6 antibody validation”或“application”。
The proteasome 20S subunit alpha 6 (PSMA6), also known as α6 or 27 kDa prosomal protein, is a critical component of the 20S core particle of the 26S proteasome, a large multiprotein complex responsible for the degradation of ubiquitinated proteins in eukaryotic cells. As part of the ubiquitin-proteasome system (UPS), PSMA6 contributes to proteolytic activities essential for maintaining cellular homeostasis, regulating processes such as cell cycle progression, apoptosis, and stress response. The 20S proteasome consists of four stacked heptameric rings (α7β7β7α7), with PSMA6 belonging to the α-ring, which serves as a regulatory gate for substrate entry.
PSMA6 antibodies are widely used in research to investigate proteasome structure, function, and dysregulation in diseases. These antibodies enable the detection and quantification of PSMA6 expression in tissues or cells via techniques like Western blotting, immunohistochemistry, and immunofluorescence. Studies have linked PSMA6 abnormalities to various pathologies, including cancer (e.g., upregulated in hepatocellular carcinoma), neurodegenerative disorders (e.g., Alzheimer’s disease), and autoimmune conditions, highlighting its potential as a therapeutic target. Additionally, PSMA6-specific antibodies aid in exploring the mechanisms of proteasome inhibitors (e.g., bortezomib) used in cancer therapy. Their specificity and reliability make them valuable tools for dissecting proteasome-related pathways and validating proteostasis networks in both physiological and pathological contexts.
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