| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| WB Predicted band size | 29 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human STX6 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
+ +
以下是关于STX6抗体的3篇文献示例(内容为示例性概括，非真实文献)：
1. **文献名称**：*"Syntaxin 6 regulates the intracellular trafficking of EGFR through SNARE complex formation"*
**作者**：Wendler F, et al.
**摘要**：该研究利用STX6特异性抗体，通过免疫共沉淀和免疫荧光技术，揭示了STX6在表皮生长因子受体(EGFR)运输中的关键作用，表明其通过SNARE复合体调控EGFR从内体到高尔基体的逆向运输。
2. **文献名称**：*"Localization and functional analysis of Syntaxin-6 in neuronal exocytosis"*
**作者**：Bock JB, et al.
**摘要**：作者使用STX6抗体进行亚细胞定位分析，发现STX6主要定位于神经元的高尔基体和内体膜，并证明其参与突触囊泡的分泌调控，为神经递质释放机制提供了新见解。
3. **文献名称**：*"Syntaxin-6 mediates amyloid precursor protein trafficking and processing in Alzheimer’s disease models"*
**作者**：Simonsen A, et al.
**摘要**：该研究通过STX6抗体敲低实验和免疫印迹分析，发现STX6异常表达会干扰淀粉样前体蛋白(APP)的运输，促进β-淀粉样蛋白生成，提示其与阿尔茨海默病病理相关。
(注：以上文献为假设性示例，实际引用时请通过PubMed、Google Scholar等平台检索真实文献并核对信息。)
STX6 antibodies target Syntaxin 6. a protein belonging to the SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptor) family, which plays a critical role in intracellular membrane trafficking. Syntaxin 6 is primarily localized to the trans-Golgi network (TGN) and endosomes, where it mediates vesicle docking and fusion processes essential for protein sorting, lysosomal biogenesis, and receptor recycling. It interacts with other SNARE proteins like VAMP4 and syntaxin 16. forming complexes that regulate retrograde transport and maintain organelle integrity. Research on STX6 has linked it to diverse cellular functions, including insulin-regulated GLUT4 translocation in adipocytes, neurotransmitter release, and autophagy. Dysregulation of Syntaxin 6 has been implicated in diseases such as cancer, neurodegenerative disorders, and diabetes, making it a focus for therapeutic exploration.
STX6 antibodies are widely used in studies to investigate protein localization, expression levels, and functional interactions. They are employed in techniques like Western blotting, immunofluorescence, and immunoprecipitation, often validated for specificity using knockout cell lines or siRNA-mediated depletion. Commercial STX6 antibodies are typically raised in rabbits or mice, targeting specific epitopes within the protein’s N- or C-terminal regions. Recent studies also utilize these antibodies to explore STX6’s role in viral entry mechanisms (e.g., SARS-CoV-2) and its interplay with autophagy-related proteins. As membrane trafficking gains attention in disease mechanisms, STX6 antibodies remain vital tools for unraveling cellular transport pathways and their pathological disruptions.
×
