| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | HTRG; HTRP; HCNGP |
| WB Predicted band size | 34 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human SAP30BP |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于SAP30BP抗体的3篇参考文献示例(文献信息为模拟，仅供参考)：
1. **文献名称**：SAP30BP interacts with the SIN3-HDAC complex and is required for transcriptional repression
**作者**：Yochum GS, et al.
**摘要**：研究揭示了SAP30BP作为SIN3-HDAC复合体的新成员，通过免疫共沉淀(Co-IP)和染色质免疫沉淀(ChIP)实验，证明其参与基因沉默过程，并依赖SAP30BP抗体验证其在复合体中的定位。
2. **文献名称**：Structural and functional analysis of SAP30BP in histone deacetylase-mediated chromatin remodeling
**作者**：Zhang Y, et al.
**摘要**：利用SAP30BP特异性抗体进行蛋白质印迹(Western blot)和免疫荧光实验，发现SAP30BP通过结合组蛋白H3K4me2标记，调控靶基因的转录抑制，并解析其结构域的关键作用。
3. **文献名称**：SAP30BP deficiency promotes acute myeloid leukemia progression via derepressing oncogenes
**作者**：Wang L, et al.
**摘要**：通过shRNA敲低和SAP30BP抗体检测，证明SAP30BP缺失导致HDAC复合体功能障碍，进而激活原癌基因表达，促进白血病细胞增殖，提示其作为潜在治疗靶点。
4. **文献名称**：Development of a monoclonal antibody against SAP30BP for clinical biomarker analysis
**作者**：Tanaka M, et al.
**摘要**：报道了一种高特异性抗SAP30BP单克隆抗体的开发，验证其在组织微阵列中的临床应用潜力，可用于癌症患者样本中SAP30BP表达水平的定量检测。
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*注：以上文献为示例性质，实际引用需根据具体研究检索PubMed、Google Scholar等数据库获取真实文献。*
The SAP30BP (SAP30-binding protein) antibody is a valuable tool for studying the role of SAP30BP in transcriptional regulation and chromatin remodeling. SAP30BP, also known as SANTA, is a conserved nuclear protein that interacts with SAP30. a component of the Sin3A/histone deacetylase (HDAC) corepressor complex. This complex plays a critical role in gene silencing by recruiting HDACs to modify histones, leading to chromatin condensation and transcriptional repression. SAP30BP is implicated in mediating interactions between the Sin3A/HDAC complex and other regulatory proteins, influencing processes like cell cycle control, apoptosis, and differentiation. Dysregulation of SAP30BP has been linked to cancers and neurological disorders, highlighting its biological significance.
The SAP30BP antibody is commonly used in applications such as Western blotting, immunofluorescence, and immunoprecipitation to detect endogenous SAP30BP expression in various cell types and tissues. It aids in elucidating SAP30BP's subcellular localization, protein-protein interactions, and involvement in epigenetic mechanisms. Researchers rely on this antibody to explore its role in disease pathways and potential therapeutic targets. Validated for specificity and sensitivity, it supports studies in cancer biology, neurobiology, and epigenetics, making it essential for dissecting SAP30BP-associated molecular networks.
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