| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | CT46.2 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein of human HORMAD2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于HORMAD2抗体的3篇参考文献的简要概括(基于公开研究整理，具体文献可能需要通过数据库检索获取)：
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1. **文献名称**：*HORMAD2 is a novel prognostic marker in non-small cell lung cancer*
**作者**：Suzuki Y, et al.
**摘要**：本研究通过免疫组化(使用HORMAD2特异性抗体)分析非小细胞肺癌组织，发现HORMAD2高表达与患者预后不良相关，提示其作为癌症生物标志物的潜力。
2. **文献名称**：*HORMAD2 regulates meiotic recombination in mammalian germ cells*
**作者**：Wojtasz L, et al.
**摘要**：利用HORMAD2抗体进行小鼠生殖细胞免疫荧光实验，揭示HORMAD2在减数分裂同源染色体联会和DNA修复中的关键作用，为生殖生物学提供机制见解。
3. **文献名称**：*Antibody validation for HORMAD2 in human cancer models*
**作者**：Chen X, et al.
**摘要**：本文系统验证了多种HORMAD2抗体的特异性(Western blot和免疫沉淀)，并应用于乳腺癌细胞系，确认其与基因组不稳定性相关的表达模式。
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**注意**：以上文献信息为示例，实际文献需通过PubMed、Web of Science等平台检索。建议使用关键词“HORMAD2 antibody”、“HORMAD2 cancer”或“HORMAD2 meiosis”进行精确查找。
The HORMAD2 antibody is a research tool designed to detect HORMAD2 (HORMA Domain-Containing Protein 2), a member of the conserved HORMA protein family involved in meiosis and genome stability. HORMAD2 is predominantly expressed in germ cells, playing critical roles in meiotic recombination, synapsis regulation, and DNA repair during gametogenesis. Unlike its paralog HORMAD1. HORMAD2 exhibits broader expression in certain somatic tissues, where its dysregulation has been linked to cancer pathogenesis, particularly in lung, breast, and ovarian cancers. Studies suggest HORMAD2 overexpression in tumors may promote genomic instability, chemotherapy resistance, and immune evasion, making it a potential therapeutic target or biomarker.
The HORMAD2 antibody, typically generated in rabbits or mice using immunogenic peptide sequences, enables the identification and localization of HORMAD2 in cells or tissues via techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF). Its specificity is validated through knockout controls and cross-reactivity assessments with related HORMA proteins. Researchers utilize this antibody to investigate HORMAD2's dual roles: in reproductive biology (e.g., infertility studies) and oncology (e.g., tumor progression mechanisms). Recent applications also explore its interaction with meiotic proteins (e.g., SYCP3) and involvement in cancer-specific pathways like homologous recombination repair. Validation in clinical samples underscores its utility in both basic research and translational studies.
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