| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | GODZ; DHHC3; DHHC-3; ZNF373 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human ZDHHC3 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于ZDHHC3抗体的3篇参考文献(示例为模拟生成，非真实文献)：
1. **文献名称**: "ZDHHC3-mediated palmitoylation regulates EGFR signaling in glioblastoma"
**作者**: Li, X. et al.
**摘要**: 研究利用ZDHHC3抗体揭示其在胶质母细胞瘤中通过棕榈酰化修饰EGFR，促进肿瘤细胞增殖和侵袭，提示其作为潜在治疗靶点。
2. **文献名称**: "Loss of ZDHHC3 impairs synaptic plasticity and memory formation in mice"
**作者**: Wang, Y. et al.
**摘要**: 通过ZDHHC3抗体检测发现，该酶在海马神经元中调控突触蛋白的棕榈酰化，缺失导致小鼠学习记忆能力下降，关联阿尔茨海默病病理。
3. **文献名称**: "ZDHHC3 antibody reveals its role in lipid raft localization of Src family kinases"
**作者**: Smith, J. et al.
**摘要**: 研究使用特异性ZDHHC3抗体证实，其通过棕榈酰化调控Src激酶在脂筏中的定位，影响肿瘤细胞的迁移和信号转导。
4. **文献名称**: "ZDHHC3 modulates antiviral immune response by palmitoylating STING"
**作者**: Chen, L. et al.
**摘要**: 利用ZDHHC3抗体进行免疫共沉淀实验，发现其通过修饰STING蛋白的棕榈酰化，抑制天然免疫信号通路，为抗病毒治疗提供新思路。
(注：以上内容为模拟生成，实际文献需通过PubMed/Google Scholar等平台检索。)
ZDHHC3 antibody is a research tool designed to detect and study the ZDHHC3 protein, a member of the DHHC (Asp-His-His-Cys) family of palmitoyltransferases. These enzymes catalyze protein palmitoylation, a post-translational modification critical for membrane anchoring, protein trafficking, and cellular signaling. ZDHHC3. encoded by the ZDHHC3 gene in humans, is primarily localized in the Golgi apparatus and endoplasmic reticulum. It plays key roles in neuronal function, synaptic plasticity, and intracellular transport by palmitoylating substrate proteins such as SNAP-25. PSD-95. and certain G-protein-coupled receptors.
Research using ZDHHC3 antibodies has linked this enzyme to neurological disorders, including Alzheimer’s disease and Huntington’s disease, where aberrant palmitoylation contributes to pathological protein aggregation. It is also implicated in cancer progression through modulation of oncogenic signaling pathways. The antibody enables detection of ZDHHC3 expression levels, subcellular localization, and interactions via techniques like Western blotting, immunohistochemistry, and immunoprecipitation. Validation typically involves knockout controls to confirm specificity. Recent studies (as of 2023) explore its therapeutic potential as a target for modulating disease-related palmitoylation pathways. Commercial availability from multiple antibody suppliers supports its widespread use in basic and translational research.
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