| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | ACS; LLPL; LPLA2; LYPLA3; GXVPLA2 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human PLA2G15 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于PLA2G15抗体的3篇模拟参考文献示例(实际文献需通过学术数据库查询)：
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1. **文献名称**: *"Characterization of PLA2G15 in lysosomal lipid metabolism using a specific polyclonal antibody"*
**作者**: Smith A, et al.
**摘要**: 本研究通过开发兔源多克隆抗体，证实PLA2G15定位于溶酶体，并参与鞘磷脂水解过程，为溶酶体脂质代谢障碍疾病提供机制线索。
2. **文献名称**: *"PLA2G15 antibody-based detection reveals its overexpression in colorectal cancer tissues"*
**作者**: Zhang L, et al.
**摘要**: 利用商业化PLA2G15单克隆抗体进行免疫组化分析，发现结直肠癌组织中PLA2G15蛋白表达显著升高，且与肿瘤转移和患者生存率负相关。
3. **文献名称**: *"Role of PLA2G15 in viral entry: Insights from antibody-mediated functional blockade"*
**作者**: Tanaka K, et al.
**摘要**: 通过PLA2G15中和抗体抑制实验，证明该酶通过调控膜脂质重组促进包膜病毒入侵，为抗病毒治疗提供潜在靶点。
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**备注**：以上为模拟示例，真实文献建议通过PubMed、Web of Science等平台以关键词“PLA2G15 antibody”或“phospholipase A2 group XV”检索获取。部分研究可能聚焦于PLA2G15的酶活性而非抗体应用，需结合具体需求筛选。
Phospholipase A2 group XV (PLA2G15), also known as Group XV secreted phospholipase A2 (GXV sPLA2), is an enzyme encoded by the *PLA2G15* gene. It belongs to the phospholipase A2 superfamily, which hydrolyzes phospholipids to generate fatty acids and lysophospholipids, playing critical roles in lipid metabolism, membrane remodeling, and cellular signaling. PLA2G15 is distinct from other sPLA2 isoforms due to its unique substrate preference for phosphatidylcholine and its association with lipoproteins. It is implicated in lipid homeostasis, inflammation, and host defense mechanisms. Dysregulation of PLA2G15 has been linked to metabolic disorders, neurodegenerative diseases, and cancer, making it a subject of interest in biomedical research.
Antibodies targeting PLA2G15 are essential tools for studying its expression, localization, and function. These antibodies, often developed in rabbit or mouse models, enable detection via techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF). Specificity is validated using knockout controls or recombinant protein assays. PLA2G15 antibodies aid in exploring its role in lipid signaling pathways, disease mechanisms, and potential therapeutic targeting. Recent studies also highlight its interaction with viral envelopes, suggesting relevance in infectious disease contexts. As research advances, PLA2G15 antibodies remain vital for unraveling its multifaceted biological contributions.
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