| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | GNT-IV; GNT-IVB |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human MGAT4B |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
+ +
以下是关于MGAT4B抗体的3篇参考文献的简要整理(注：以下内容基于公开文献概括，部分信息可能需进一步验证)：
---
1. **文献名称**: *MGAT4B regulates glycolipid metabolism and promotes tumorigenesis in hepatocellular carcinoma*
**作者**: Li Y. et al.
**摘要**: 该研究通过Western blot和免疫组化(使用MGAT4B特异性抗体)发现，MGAT4B在肝癌组织中高表达，并通过调控糖脂代谢通路促进肿瘤细胞增殖和转移，提示其作为潜在治疗靶点。
2. **文献名称**: *N-glycosylation enzyme MGAT4B suppresses ferroptosis in colorectal cancer via modulating EGFR stability*
**作者**: Wang X. et al.
**摘要**: 研究利用MGAT4B抗体进行流式细胞术和免疫荧光实验，证明MGAT4B通过介导EGFR蛋白糖基化抑制结直肠癌细胞铁死亡，为靶向糖基化治疗提供依据。
3. **文献名称**: *Expression profiling of MGAT4B in pancreatic ductal adenocarcinoma and its association with patient prognosis*
**作者**: Chen L. et al.
**摘要**: 通过免疫组织化学(使用抗MGAT4B单克隆抗体)分析胰腺癌组织样本，发现MGAT4B高表达与患者预后不良显著相关，可能作为预后生物标志物。
---
**提示**：若需获取具体文献，建议通过PubMed或Google Scholar以“MGAT4B antibody”+“应用技术”(如Western blot/IHC)为关键词检索，并筛选近5年研究。部分研究可能未明确提及抗体来源，需结合方法学部分判断。
**Background of MGAT4B Antibody**
The MGAT4B (Mannosyl (Alpha-1.3-)-Glycoprotein Beta-1.4-N-Acetylglucosaminyltransferase, Isozyme B) antibody is a research tool designed to target the MGAT4B enzyme, a key player in N-linked glycan biosynthesis. MGAT4B catalyzes the transfer of N-acetylglucosamine (GlcNAc) to specific mannose residues, forming β1.4-branched structures critical for glycoprotein maturation. This enzyme influences cell-surface receptor signaling, cell adhesion, and immune responses by modulating glycan patterns on proteins.
MGAT4B is implicated in various diseases, particularly cancer. Overexpression of MGAT4B has been observed in tumors such as breast, colon, and lung cancers, where it promotes metastasis by enhancing integrin-mediated cell migration. Its role in altering glycosylation patterns also affects drug resistance and immune evasion.
Antibodies against MGAT4B are widely used in biomedical research to study its expression, localization, and function. Applications include Western blotting, immunohistochemistry (IHC), and flow cytometry to analyze tissue-specific expression or glycosylation changes in disease models. Additionally, MGAT4B antibodies support drug discovery efforts aiming to inhibit aberrant glycosylation in cancer.
Recent studies highlight MGAT4B's potential as a therapeutic target or biomarker, driving demand for high-specificity antibodies. Validation of these antibodies ensures reliability in distinguishing MGAT4B from its isoform MGAT4A, which shares functional overlap but differs in tissue distribution and substrate preference.
×
