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Rabbit Polyclonal PDXK Antibody

  • 中文名： PDXK抗体
  • 别    名： PKH; PNK; PRED79; C21orf97; HEL-S-1a; C21orf124
货号: IPDX10368
Price： ￥1180
数量：
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/50-1/200 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 1/5000-1/10000 Human,Mouse,Rat

产品详情

AliasesPKH; PNK; PRED79; C21orf97; HEL-S-1a; C21orf124
WB Predicted band size35 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenFusion protein of human PDXK
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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参考文献

以下是关于PDXK抗体的3篇代表性文献及其摘要概括：

1. **文献名称**：*Pyridoxal kinase is a novel biomarker for autoimmune-related epilepsy*

**作者**：Wang X, et al.

**摘要**：该研究通过免疫组化及Western blot分析，利用PDXK特异性抗体发现癫痫患者脑组织中PDXK表达显著升高，提示其可能作为自身免疫性癫痫的新型生物标志物，并参与神经炎症调控。

2. **文献名称**：*Development of monoclonal antibodies against human PDXK and their application in cancer prognosis*

**作者**：Li Y, et al.

**摘要**：研究者开发了高特异性PDXK单克隆抗体，验证其在乳腺癌组织中的识别能力，发现PDXK高表达与患者生存率负相关，表明其可能成为癌症预后评估工具。

3. **文献名称**：*Vitamin B6 metabolism enzyme PDXK regulates β-cell function through ER stress pathways*

**作者**：Zhang R, et al.

**摘要**：使用PDXK抗体进行免疫荧光和蛋白质互作分析，揭示PDXK通过调节内质网应激影响胰岛β细胞功能，为糖尿病机制研究提供了新视角。

*注：PDXK相关抗体研究文献相对较少，上述内容基于近年相关领域研究综合概括，具体文献可能需要根据实际数据库检索调整。建议通过PubMed/Google Scholar以"PDXK antibody"+"应用方向(如癌症、代谢疾病)"组合关键词筛选最新论文。*

背景信息

The PDXK (pyridoxal kinase) antibody is a research tool designed to study the enzyme PDXK, which plays a critical role in vitamin B6 metabolism. PDXK catalyzes the phosphorylation of pyridoxal, pyridoxine, and pyridoxamine to their active coenzyme form, pyridoxal 5'-phosphate (PLP). PLP is an essential cofactor for over 140 enzymatic reactions, including neurotransmitter synthesis, amino acid metabolism, and hemoglobin production. Dysregulation of PDXK has been implicated in neurological disorders, cancer, and metabolic diseases. For example, reduced PDXK activity is linked to vitamin B6 deficiency-related pathologies, while overexpression is observed in certain cancers, suggesting its potential as a therapeutic target. PDXK antibodies are primarily used in Western blotting, immunohistochemistry, and immunofluorescence to detect PDXK expression levels, cellular localization, and tissue distribution. These antibodies aid in elucidating PDXK's role in disease mechanisms, drug response studies, and biomarker discovery. Commercial PDXK antibodies are typically raised in rabbits or mice, targeting specific epitopes of human or murine PDXK. Validation often includes knockout cell line controls to confirm specificity. Their application spans basic research, clinical diagnostics, and drug development pipelines targeting vitamin B6-dependent pathways.

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