Rabbit Polyclonal PDXK Antibody

The PDXK (pyridoxal kinase) antibody is a research tool designed to study the enzyme PDXK, which plays a critical role in vitamin B6 metabolism. PDXK catalyzes the phosphorylation of pyridoxal, pyridoxine, and pyridoxamine to their active coenzyme form, pyridoxal 5'-phosphate (PLP). PLP is an essential cofactor for over 140 enzymatic reactions, including neurotransmitter synthesis, amino acid metabolism, and hemoglobin production. Dysregulation of PDXK has been implicated in neurological disorders, cancer, and metabolic diseases. For example, reduced PDXK activity is linked to vitamin B6 deficiency-related pathologies, while overexpression is observed in certain cancers, suggesting its potential as a therapeutic target. PDXK antibodies are primarily used in Western blotting, immunohistochemistry, and immunofluorescence to detect PDXK expression levels, cellular localization, and tissue distribution. These antibodies aid in elucidating PDXK's role in disease mechanisms, drug response studies, and biomarker discovery. Commercial PDXK antibodies are typically raised in rabbits or mice, targeting specific epitopes of human or murine PDXK. Validation often includes knockout cell line controls to confirm specificity. Their application spans basic research, clinical diagnostics, and drug development pipelines targeting vitamin B6-dependent pathways.