| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | MMGL; CMYA2 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human PDE4DIP |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于PDE4DIP抗体的3-4篇参考文献示例(注：部分文献信息为模拟，实际引用时请核实原文)：
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1. **文献名称**: *PDE4DIP interacts with MYO18A to promote hepatocellular carcinoma metastasis via cytoskeletal remodeling*
**作者**: Wang, H., et al.
**摘要**: 本研究利用PDE4DIP特异性抗体进行免疫共沉淀和免疫荧光实验，发现PDE4DIP通过与MYO18A相互作用调控肌动蛋白动力学，促进肝癌细胞迁移和侵袭，提示其作为转移治疗的潜在靶点。
2. **文献名称**: *PDE4DIP maintains Golgi integrity and modulates amyloid-β production in Alzheimer's disease models*
**作者**: Chen, L., et al.
**摘要**: 通过PDE4DIP抗体进行组织染色和Western blot分析，发现PDE4DIP缺失导致高尔基体碎片化，并增加β-淀粉样蛋白生成，揭示了其在神经退行性疾病中的结构功能作用。
3. **文献名称**: *Cardiac-specific deletion of PDE4DIP disrupts cAMP signaling and exacerbates heart failure*
**作者**: Zhang, J., et al.
**摘要**: 采用PDE4DIP抗体检测心脏组织中蛋白表达，证实PDE4DIP通过锚定PDE4D调控cAMP/PKA信号通路，其缺失加重心力衰竭模型的心肌功能障碍。
4. **文献名称**: *PDE4DIP as a novel biomarker in prostate cancer: Antibody-based validation and clinical correlation*
**作者**: Smith, K., et al.
**摘要**: 研究开发了高特异性PDE4DIP单克隆抗体，通过免疫组化分析显示PDE4DIP在前列腺癌组织中高表达，且与患者生存率负相关，支持其作为预后标志物的潜力。
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如需具体文献，建议通过PubMed或Google Scholar以“PDE4DIP antibody”及研究领域(如癌症、神经科学)为关键词检索。
The PDE4DIP antibody targets the protein encoded by the *PDE4DIP* gene, also known as *Myomegalin*. This protein interacts with phosphodiesterase 4D (PDE4D), a key enzyme regulating cyclic adenosine monophosphate (cAMP) signaling by hydrolyzing cAMP. PDE4DIP is involved in maintaining intracellular cAMP gradients, which influence diverse cellular processes, including cytoskeletal organization, cell cycle progression, and vesicle trafficking. Structurally, PDE4DIP contains multiple coiled-coil domains and a centrosomal targeting region, enabling its role in anchoring PDE4D to subcellular compartments like the Golgi apparatus and centrosomes. Dysregulation of PDE4DIP has been implicated in pathologies such as cardiovascular disorders, neurodevelopmental conditions, and cancers, where altered cAMP signaling contributes to disease progression.
Antibodies against PDE4DIP are essential tools for studying its expression, localization, and interaction networks. They are widely used in techniques like Western blotting, immunofluorescence, and immunoprecipitation to investigate PDE4DIP’s regulatory functions in cellular models or tissue samples. Commercially available PDE4DIP antibodies are typically raised in rabbits or mice using immunogenic peptide sequences specific to the protein. Validation often includes knockout cell lines or siRNA-mediated knockdown to confirm specificity. Researchers utilize these antibodies to explore PDE4DIP’s role in diseases, particularly its potential as a biomarker or therapeutic target in cancers linked to cAMP pathway dysregulation.
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