| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | ICA69; ICAp69 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human ICA1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于ICA1抗体的3篇参考文献示例(注：以下文献为虚构示例，仅用于演示格式，建议通过PubMed或Google Scholar获取真实文献)：
1. **文献名称**: *Islet Cell Autoantibody 1 (ICA1) as a Biomarker in Early Type 1 Diabetes Prediction*
**作者**: Smith A, Johnson B
**摘要**: 本研究分析了ICA1抗体在1型糖尿病高危人群中的预测价值，发现其与β细胞破坏显著相关，联合其他自身抗体可提高疾病风险评估准确性。
2. **文献名称**: *Molecular Characterization of ICA1 Autoantigen in Pancreatic β-Cells*
**作者**: Lee C, Patel R
**摘要**: 通过免疫沉淀和质谱技术鉴定了ICA1蛋白的抗原表位，揭示了其在胰岛细胞中的表达模式及与自身免疫攻击的关联机制。
3. **文献名称**: *ICA1 Antibodies in Pediatric Diabetes: A Longitudinal Cohort Study*
**作者**: Garcia M, et al.
**摘要**: 对500名儿童进行10年追踪，发现ICA1抗体阳性个体发展为临床糖尿病的风险比阴性者高3倍，提示其作为早期筛查工具的重要性。
**提示**：实际研究中，可检索关键词“ICA1 antibody”、“islet cell autoantibody 1”及“type 1 diabetes”获取权威文献，如Nature、Diabetes Care等期刊的论文。
The ICA1 (Islet Cell Autoantigen 1) antibody is associated with autoimmune responses in type 1 diabetes (T1D). ICA1. a protein encoded by the *ICA1* gene, is expressed in pancreatic islet cells and neuroendocrine tissues. It plays roles in secretory processes, particularly in neurotransmitter and hormone release. Structurally, ICA1 contains a protein tyrosine phosphatase (PTP)-like domain, though its enzymatic activity remains unclear.
In T1D, ICA1 antibodies are detected as part of the autoimmune attack on insulin-producing beta cells. These autoantibodies, alongside others like GAD65 or IA-2 antibodies, serve as biomarkers for predicting disease risk and progression. ICA1 antibodies are less common than other T1D-associated autoantibodies but are linked to early-onset or aggressive disease.
Research highlights two ICA1 isoforms: ICA1-L (long) and ICA1-VAg (variant antigen). ICA1-VAg, localized to synaptic vesicles, may trigger cross-reactive immune responses due to molecular mimicry with viral antigens, suggesting an environmental trigger in genetically predisposed individuals. Studies also explore ICA1's role in neurodevelopmental disorders, though its clinical significance here is less defined.
Clinically, ICA1 antibody testing aids in T1D diagnosis and risk stratification, especially in asymptomatic individuals with a family history. However, standardization of assays and further validation of its prognostic utility remain ongoing challenges. Understanding ICA1's function and immunogenicity continues to inform autoimmune diabetes research and therapeutic strategies.
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