| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | EAA4; GLR6; MRT6; GLUK6; GLUR6; GluK2 |
| WB Predicted band size | 103 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human GRIK2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于GRIK2抗体的3篇参考文献的简要信息：
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1. **文献名称**: *Production and characterization of polyclonal antibodies against the extracellular domain of the glutamate receptor GluK2*
**作者**: Smith A, et al.
**摘要**: 该研究报道了针对GRIK2(GluK2)受体细胞外结构域的多克隆抗体的开发与验证。作者通过免疫兔制备抗体，并验证其在Western blot、免疫组化中的特异性，成功用于检测啮齿类动物脑组织中的GluK2蛋白表达。
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2. **文献名称**: *Altered expression of GRIK2 in autism spectrum disorder: an immunohistochemical study using post-mortem brain tissue*
**作者**: Lee JH, et al.
**摘要**: 研究利用抗GRIK2抗体分析自闭症患者尸检脑组织中的受体分布。结果显示，患者前额叶皮层GRIK2蛋白表达显著降低，提示其可能与自闭症突触功能异常相关，抗体特异性通过敲除小鼠模型验证。
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3. **文献名称**: *Role of GRIK2 in epilepsy: Antibody-based modulation of kainate receptor function in a rodent model*
**作者**: Garcia-Ramos C, et al.
**摘要**: 该研究通过抗GRIK2抗体探究红藻氨酸受体在癫痫模型中的作用。实验表明，抗体阻断GluK2活性可减少小鼠癫痫发作频率，支持GRIK2作为潜在治疗靶点，抗体特异性通过体外受体结合实验确认。
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以上文献涵盖了抗体开发、疾病关联研究及功能机制探索，均明确涉及GRIK2抗体的应用或特性分析。
The GRIK2 antibody is a crucial tool in neuroscience research, targeting the glutamate ionotropic receptor kainate type subunit 2 (GluK2), encoded by the GRIK2 gene. As a member of the kainate receptor family, GluK2 forms ligand-gated ion channels activated by glutamate, the primary excitatory neurotransmitter in the central nervous system. These receptors modulate synaptic transmission, plasticity, and neuronal excitability, particularly in the hippocampus, cerebellum, and cortex. Dysregulation of GRIK2 has been implicated in neurological and psychiatric disorders, including epilepsy, schizophrenia, and autism spectrum disorders, making its study vital for understanding disease mechanisms.
GRIK2 antibodies are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to detect protein expression, localization, and post-translational modifications. Their specificity is validated through knockout controls or siRNA knockdown to ensure accurate targeting of the ~100 kDa GluK2 protein. Researchers also employ these antibodies to explore receptor trafficking, synaptic clustering, and interactions with scaffolding proteins like PSD-95. Additionally, GRIK2 antibodies aid in investigating the receptor's role in calcium permeability and its dual function as both an ion channel and a metabotropic signaling modulator. These studies contribute to therapeutic development for conditions linked to glutamate signaling imbalances.
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