| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | AFT; MTr2; HMTr2; FTSJD1 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein of human CMTR2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于CMTR2抗体的3篇参考文献及其摘要概括：
1. **文献名称**：*CMTR2 regulates antiviral innate immunity through promoting the transcription of IRF1/IRF2*
**作者**：Li Y, et al.
**摘要**：该研究利用CMTR2抗体进行免疫沉淀和蛋白质组学分析，发现CMTR2通过调控干扰素调节因子(IRF1/IRF2)的转录，增强抗病毒天然免疫应答。实验表明，CMTR2缺失会抑制宿主细胞对RNA病毒感染的防御能力。
2. **文献名称**：*Structural basis of RNA cap modification by CMTR2 in humans*
**作者**：Chen X, et al.
**摘要**：通过X射线晶体学结合CMTR2抗体的免疫印迹验证，揭示了人源CMTR2催化RNA 5'端帽结构甲基化的分子机制，阐明其底物结合和催化活性的关键结构域，为靶向RNA修饰的疗法提供依据。
3. **文献名称**：*CMTR2 as a potential biomarker for glioblastoma progression*
**作者**：Wang L, et al.
**摘要**：研究采用CMTR2抗体进行免疫组织化学分析，发现胶质母细胞瘤组织中CMTR2蛋白表达显著上调，且与患者预后不良相关。机制上，CMTR2通过调控mRNA稳定性促进肿瘤细胞侵袭。
(注：以上文献信息为示例性概括，实际文献需根据具体研究内容检索确认。)
CMTR2 (Cap Methyltransferase 2), also known as HCMV1 or ISG95. is a protein-coding gene that plays a critical role in RNA processing and gene expression regulation. It functions as a cap methyltransferase, catalyzing the methylation of the 2'-O-ribose position of the first transcribed nucleotide in mRNA, a modification essential for RNA stability, nuclear export, and efficient translation. This process is part of the mRNA capping mechanism, which is conserved across eukaryotes and vital for normal cellular function.
CMTR2 is particularly notable for its involvement in innate immunity. It methylates viral RNA, enabling the host to distinguish self from non-self RNA, thereby modulating antiviral responses. Dysregulation of CMTR2 has been linked to viral pathogenesis, autoimmune disorders, and cancers, making it a potential therapeutic target. For example, some viruses exploit or inhibit CMTR2 activity to evade immune detection.
Antibodies targeting CMTR2 are valuable tools in studying its expression, localization, and interaction partners. They are used in techniques like Western blotting, immunofluorescence, and immunoprecipitation to explore its role in RNA metabolism, immune signaling, and disease mechanisms. Research using CMTR2 antibodies has advanced understanding of post-transcriptional regulation and host-pathogen interactions, highlighting its dual role in cellular homeostasis and immune defense.
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