Rabbit Polyclonal PLEKHJ1 Antibody

The PLEKHJ1 antibody is a research tool designed to detect and study the PLEKHJ1 protein, encoded by the PLEKHJ1 (Pleckstrin Homology and Jockey 1) gene. This gene, located on human chromosome 19. is implicated in various cellular processes, though its precise biological functions remain under investigation. PLEKHJ1 is thought to interact with cytoskeletal components or signaling pathways, potentially influencing cell motility, membrane dynamics, or intracellular trafficking. Dysregulation of PLEKHJ1 has been loosely associated with neurological disorders and cancer, though mechanistic insights are limited. The antibody, typically developed in hosts like rabbits or mice, enables detection via techniques such as Western blotting, immunofluorescence, or immunohistochemistry. Commercial versions are available (e.g., from Abcam or Novus Biologicals), often validated for specificity using knockout controls or siRNA knockdowns. Researchers employ this antibody to explore PLEKHJ1 expression patterns across tissues, its subcellular localization, and its role in disease models. Despite its utility, challenges persist in standardizing experimental conditions due to variable protein expression levels and limited functional data. Ongoing studies aim to clarify PLEKHJ1’s molecular interactions and therapeutic relevance, positioning the antibody as a critical reagent for unraveling its pathophysiological significance.