| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/200-1/400 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | ILBP; I-15P; I-BAP; ILBP3; ILLBP; I-BABP; I-BALB |
| WB Predicted band size | 14 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human FABP6 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于FABP6抗体的3篇参考文献示例(注：以下内容为模拟示例，非真实文献)：
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1. **文献名称**：*"Development and Application of a Novel FABP6 Antibody for Studying Bile Acid Transport in Intestinal Cells"*
**作者**：M. Tanaka et al.
**摘要**：本研究开发了一种高特异性的FABP6(回肠胆汁酸结合蛋白)多克隆抗体，并通过免疫组化和Western blot验证其在小鼠及人类肠道组织中的表达。结果显示，FABP6在回肠上皮细胞中高表达，且与胆汁酸转运功能密切相关。
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2. **文献名称**：*"FABP6 Overexpression in Gastric Cancer: Correlation with Lipid Metabolism via Antibody-based Proteomic Analysis"*
**作者**：L. Chen et al.
**摘要**：利用商业化FABP6抗体(货号abXXXXX)对胃癌组织进行免疫组织化学分析，发现FABP6蛋白表达显著升高，并与肿瘤细胞的脂质代谢重编程相关，提示其可能作为胃癌潜在生物标志物。
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3. **文献名称**：*"Role of FABP6 in Cholesterol Homeostasis: Insights from Knockout Mouse Models Using Antibody-mediated Detection"*
**作者**：R. Kumar et al.
**摘要**：通过FABP6抗体对野生型和FABP6敲除小鼠的肠道及肝脏组织进行蛋白定位分析，发现FABP6缺失导致胆汁酸吸收障碍，证实其在胆固醇稳态中的关键作用。
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(注：如需真实文献，建议通过PubMed或Google Scholar检索关键词“FABP6 antibody”或“I-BABP antibody”，并筛选涉及实验应用的论文。)
**Background of FABP6 Antibody**
Fatty acid-binding protein 6 (FABP6), also known as ileal bile acid-binding protein (I-BABP), is a cytoplasmic protein primarily expressed in the distal ileum. It belongs to the FABP family, which facilitates the intracellular transport and metabolism of lipids, including bile acids. FABP6 plays a critical role in the enterohepatic circulation of bile acids by binding to bile salts in the ileum, aiding their absorption and transport to the liver. This process is essential for maintaining cholesterol homeostasis, lipid digestion, and signaling pathways regulated by bile acids.
FABP6 antibodies are essential tools for studying the expression, localization, and function of FABP6 in physiological and pathological contexts. They are widely used in techniques such as Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to investigate FABP6’s role in intestinal diseases, metabolic disorders, and cancers. Dysregulation of FABP6 has been linked to colorectal cancer, gallstone formation, and inflammatory bowel diseases (IBD), making it a potential biomarker or therapeutic target.
These antibodies are typically raised against specific epitopes of human or murine FABP6. ensuring species-specific reactivity. Validation includes testing for cross-reactivity with other FABP family members (e.g., FABP1. FABP2) to confirm specificity. Commercial FABP6 antibodies are available in monoclonal or polyclonal formats, catering to diverse research needs. Ongoing studies continue to explore FABP6’s interaction with nuclear receptors (e.g., FXR) and its impact on lipid metabolism, highlighting its significance in both basic and clinical research.
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