Rabbit Polyclonal DYNLRB1 Antibody

The DYNLRB1 antibody is a tool used to detect and study dynein light chain roadblock-type 1 (DYNLRB1), a component of the cytoplasmic dynein motor protein complex. Cytoplasmic dynein is critical for intracellular transport, facilitating the movement of organelles, vesicles, and molecular cargo along microtubules toward the cell center (minus-end directed transport). DYNLRB1. a member of the roadblock/LC7 family of dynein light chains, plays roles in regulating dynein activity, cargo binding, and interaction with regulatory proteins. It is implicated in diverse cellular processes, including mitotic spindle organization, Golgi apparatus positioning, and neuronal transport. Dysregulation of dynein function is linked to neurodegenerative diseases, developmental defects, and cancer. The DYNLRB1 antibody is commonly used in techniques like Western blotting, immunofluorescence, and immunoprecipitation to analyze protein expression, localization, and interactions in cell or tissue samples. Its applications span basic research on intracellular trafficking mechanisms, studies of dynein-associated pathologies, and validation of experimental models involving DYNLRB1 knockdown or overexpression. Validation of antibody specificity, often via knockout controls, is essential due to potential cross-reactivity with homologous proteins.