| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/200-1/300 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | FKBP-3; FKBP25; PPIase; FKBP-25 |
| WB Predicted band size | 25 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human FKBP3 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于FKBP3抗体的3篇参考文献概览(基于公开研究总结，非真实引用)：
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1. **标题**：*FKBP3 promotes prostate cancer cell proliferation by modulating androgen receptor signaling*
**作者**：Sato T, et al.
**摘要**：该研究通过免疫沉淀(使用FKBP3抗体)和功能实验发现，FKBP3与雄激素受体(AR)结合并增强其稳定性，从而促进前列腺癌细胞增殖，提示FKBP3可作为潜在治疗靶点。
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2. **标题**：*FKBP3 interacts with Tau and regulates its aggregation in Alzheimer's disease models*
**作者**：Jinwal UK, et al.
**摘要**：研究利用FKBP3抗体进行共定位分析，发现FKBP3在阿尔茨海默病模型中与Tau蛋白相互作用，抑制其异常聚集，可能通过分子伴侣功能减缓神经退行性病变。
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3. **标题**：*FKBP3 mediates cardiac hypertrophy through mTOR pathway activation*
**作者**：Miyamoto S, et al.
**摘要**：通过Western blot(使用FKBP3抗体)和基因敲除实验，证实FKBP3通过激活mTOR信号通路驱动心肌细胞肥大，为心脏肥厚机制提供了新见解。
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**注**：以上为模拟示例，实际文献需通过数据库(如PubMed)检索。建议结合具体研究方向补充关键词(如“FKBP3 antibody application”或“FKBP3 in [疾病/机制]”)获取真实文献。
The FKBP3 antibody is a tool used to detect FK506-binding protein 3 (FKBP3), also known as FKBP25. a member of the immunophilin protein family. FKBP3 belongs to the FKBP subfamily, characterized by peptidyl-prolyl cis-trans isomerase (PPIase) activity, which assists in protein folding and modulates signaling pathways. This 25 kDa protein contains a nuclear localization signal and is primarily found in the nucleus, where it interacts with chromatin-remodeling complexes, histones, and transcription factors. Its role in regulating enzymatic activity or signaling cascades remains partially understood, but it has been implicated in cellular stress responses, apoptosis, and epigenetic regulation.
FKBP3 antibodies are widely employed in research to study protein localization, expression levels, and interactions via techniques like Western blotting, immunoprecipitation, and immunofluorescence. Dysregulation of FKBP3 has been observed in cancer, neurodegenerative diseases, and immune disorders, making it a potential biomarker or therapeutic target. For instance, FKBP3 overexpression in certain cancers correlates with chemoresistance, while its interaction with tau protein in Alzheimer’s models suggests involvement in neuropathology.
These antibodies are critical for elucidating FKBP3’s molecular mechanisms and validating its involvement in disease pathways, aiding drug discovery and functional genomics studies.
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