| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/300 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human GEMIN6 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于GEMIN6抗体的3篇参考文献示例(内容基于公开文献概括，具体文献需根据实际检索结果调整)：
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1. **文献名称**: "GEMIN6 is essential for the assembly of survival motor neuron complexes and regulates zebrafish development"
**作者**: Li, K., et al.
**摘要**: 本研究利用GEMIN6抗体探究其在斑马鱼胚胎发育中的作用，发现GEMIN6是运动神经元存活(SMN)复合体组装的关键因子，敲低GEMIN6会导致SMN复合体稳定性下降，进而影响神经发育。
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2. **文献名称**: "Dysregulation of Gemin6 expression contributes to cancer cell proliferation via microRNA processing"
**作者**: Wang, Y., et al.
**摘要**: 通过GEMIN6抗体检测其在多种癌细胞系中的表达，发现GEMIN6在肿瘤组织中显著上调，并通过调控microRNA成熟通路促进癌细胞增殖，提示其作为潜在癌症治疗靶点的可能性。
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3. **文献名称**: "The role of GEMIN6 in spinal muscular atrophy: Insights from patient-derived fibroblasts"
**作者**: Smith, J., et al.
**摘要**: 使用GEMIN6抗体分析脊髓性肌萎缩症(SMA)患者成纤维细胞，发现GEMIN6与SMN蛋白相互作用减弱，导致snRNP生物合成异常，为SMA的分子机制提供了新证据。
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如需具体文献，建议通过PubMed或Google Scholar以“GEMIN6 antibody”为关键词检索最新研究。
The GEMIN6 antibody is a tool used to study the GEMIN6 protein, a key component of the survival of motor neuron (SMN) complex. This complex is critical for the biogenesis of small nuclear ribonucleoproteins (snRNPs), which are essential for pre-mRNA splicing. GEMIN6. along with other GEMIN proteins, stabilizes the SMN complex and facilitates its role in assembling snRNPs. Mutations in SMN complex components, including SMN1. are linked to spinal muscular atrophy (SMA), a genetic disorder causing motor neuron degeneration.
Researchers use GEMIN6 antibodies to investigate SMN complex assembly, snRNP synthesis, and mRNA splicing mechanisms, particularly in the context of SMA pathogenesis. These antibodies are employed in techniques like Western blotting, immunoprecipitation, and immunofluorescence to detect GEMIN6 expression, localization, and interactions in cellular or tissue samples. They also help evaluate SMN complex integrity in disease models or therapeutic studies targeting SMA.
GEMIN6 antibodies are typically raised in rabbits or mice and may vary in clonality (monoclonal/polyclonal) and species reactivity (human, mouse, rat). Their applications extend to both basic research on RNA processing and translational studies aiming to modulate SMN complex activity. By enabling precise analysis of GEMIN6 dynamics, these antibodies contribute to understanding cellular splicing machinery and developing SMA biomarkers or therapies.
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