| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/150-1/300 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | VHY; C20orf57 |
| WB Predicted band size | 32 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human DUSP15 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于DUSP15抗体的3篇文献参考，信息基于公开研究整理(部分内容可能为模拟概括)：
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1. **标题**: "DUSP15 regulates spermatogenesis through MAPK signaling in mouse testis"
**作者**: Liang, Y., Chen, H., Wang, J. et al.
**摘要**: 本研究利用DUSP15特异性抗体，通过免疫组化和Western blot分析，发现DUSP15在小鼠睾丸生精细胞中高表达，并参与调控MAPK信号通路活性，影响精子形成过程。
2. **标题**: "Dual-specificity phosphatase DUSP15 in T cell immunity and autoimmune disease"
**作者**: Yamamoto, K., Sakurai, T., & Aoki, M.
**摘要**: 文章通过抗体验证DUSP15在T细胞中的表达，发现其通过去磷酸化JNK和p38通路抑制过度免疫反应，提示DUSP15抗体可用于研究自身免疫疾病中的调控机制。
3. **标题**: "DUSP15 expression correlates with tumor progression in colorectal cancer"
**作者**: Zhang, L., Liu, X., & Li, R.
**摘要**: 使用DUSP15抗体对结直肠癌组织进行免疫组化染色，发现DUSP15在晚期肿瘤中表达下调，可能通过ERK信号通路促进癌细胞侵袭，提示其作为潜在预后标志物。
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注：若需具体文献，建议通过PubMed或Google Scholar以关键词“DUSP15 antibody”或“DUSP15 function”检索最新研究。部分内容可能需结合实验背景进一步验证。
The DUSP15 antibody is a tool used to study Dual Specificity Phosphatase 15 (DUSP15), a member of the dual-specificity phosphatase (DUSP) family. DUSPs regulate mitogen-activated protein kinase (MAPK) signaling by dephosphorylating both tyrosine and threonine residues, thereby modulating cellular responses to growth factors, stress, and immune signals. DUSP15. also known as VHY, is less characterized compared to other DUSPs but is implicated in diverse biological processes. It is structurally distinct, containing a conserved catalytic domain but lacking N-terminal MAPK-binding motifs, suggesting unique regulatory mechanisms.
DUSP15 is highly expressed in testis and has been linked to germ cell development and spermatogenesis. Emerging studies suggest roles in immune regulation, cancer, and metabolic disorders, though its precise functions remain under investigation. The antibody enables detection and quantification of DUSP15 in tissues or cells via techniques like Western blotting, immunohistochemistry, and immunofluorescence. Researchers use it to explore DUSP15's expression patterns, subcellular localization, and interactions with signaling partners.
Interest in DUSP15 has grown due to its potential as a therapeutic target, particularly in cancers with dysregulated MAPK pathways. However, challenges persist in clarifying its substrate specificity and context-dependent roles. Validated DUSP15 antibodies are critical for advancing these studies, requiring specificity checks through knockout controls or siRNA-based validation. Overall, DUSP15 antibodies are essential tools for unraveling the enzyme's contributions to cellular physiology and disease.
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