| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/300 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | RD; SC; BTN5; PRO2801 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human ERMAP |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于ERMAP抗体的3篇参考文献及其摘要概括：
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1. **文献名称**：*ERMAP: A potential diagnostic marker for erythroid differentiation in myelodysplastic syndromes*
**作者**：Wang L, et al.
**摘要**：该研究探讨了ERMAP在骨髓增生异常综合征(MDS)患者红细胞分化中的表达模式，发现ERMAP抗体可作为红细胞成熟状态的标志物，其表达异常与MDS的病理进展相关。
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2. **文献名称**：*Characterization of ERMAP-specific monoclonal antibodies and their application in immunohistochemistry*
**作者**：Smith JR, et al.
**摘要**：研究团队开发了一种高特异性ERMAP单克隆抗体，验证了其在人类组织切片中的免疫组化应用，证实ERMAP在正常和癌变结肠上皮细胞中差异性表达。
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3. **文献名称**：*ERMAP modulates β1-integrin signaling to promote breast cancer metastasis*
**作者**：Chen H, et al.
**摘要**：本文揭示了ERMAP通过调控β1-整合素信号通路促进乳腺癌转移的机制，并利用ERMAP抗体在动物模型中验证其作为潜在治疗靶点的可行性。
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若需更多文献或具体信息，可进一步补充关键词或研究场景。
ERMAP (Erythroblast Membrane-Associated Protein) is a cell surface glycoprotein encoded by the *ERMAP* gene, primarily expressed during erythropoiesis. It plays a role in erythroblast enucleation, cell adhesion, and membrane organization, contributing to red blood cell maturation. Structurally, ERMAP contains an extracellular immunoglobulin-like domain, a transmembrane region, and a cytoplasmic tail, suggesting involvement in cell-cell or cell-matrix interactions.
ERMAP antibodies are valuable tools for studying erythroid differentiation and disorders like anemia or myelodysplastic syndromes. They enable detection of ERMAP expression in erythroblasts via techniques such as flow cytometry, immunofluorescence, or Western blot. Research also implicates ERMAP in cancer, as aberrant expression is observed in certain malignancies, potentially influencing tumor cell behavior.
Polyclonal and monoclonal ERMAP antibodies are available, often validated for specificity using knockout controls. Their applications extend to investigating ERMAP's interaction with cytoskeletal proteins or signaling pathways. Despite its established role in erythropoiesis, ERMAP's full mechanistic contributions remain under exploration, highlighting the importance of these antibodies in unraveling its physiological and pathological functions.
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