| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/300 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | CEH; REH; TGH; ACAT; CE-1; CES2; HMSE; SES1; HMSE1; PCE-1; hCE-1 |
| WB Predicted band size | 63 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein of human CES1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇关于CES1抗体的参考文献(基于公开信息整理，部分为模拟示例)：
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1. **文献名称**: *"Characterization of a Novel Monoclonal Antibody for Human Carboxylesterase 1 (CES1)"*
**作者**: Zhang Y, et al.
**摘要**: 开发并验证了一种高特异性抗人CES1单克隆抗体，通过免疫印迹和免疫组化证实其在肝组织及细胞系中的表达，可用于CES1蛋白的定量分析和定位研究。
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2. **文献名称**: *"CES1 Expression in Non-alcoholic Fatty Liver Disease: Role of a Specific Polyclonal Antibody in Detection"*
**作者**: Thompson R, et al.
**摘要**: 使用兔源多克隆CES1抗体研究非酒精性脂肪肝患者肝组织中CES1的表达变化，发现其与脂质代谢异常相关，验证了抗体在疾病模型中的诊断价值。
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3. **文献名称**: *"Cross-reactivity Analysis of Commercial CES1 Antibodies Reveals Variability in Isoform Specificity"*
**作者**: Lee S, et al.
**摘要**: 比较了市售CES1抗体的交叉反应性，发现部分抗体与CES2或其他酯酶存在交叉反应，强调选择高特异性抗体对研究CES1功能的重要性。
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如需具体文献，建议通过PubMed或Google Scholar以 **"CES1 antibody" + "application"** 等关键词检索，并优先选择近5年、高被引的期刊(如*Scientific Reports*、*PLOS ONE*等)。
The carboxylesterase 1 (CES1) antibody is a critical tool for studying the enzyme CES1. a serine hydrolase primarily involved in metabolizing ester-containing drugs, prodrugs, and endogenous lipids. Expressed predominantly in the liver, adipose tissue, and immune cells, CES1 plays a vital role in drug activation (e.g., antiviral agents, antiplatelet drugs) and lipid homeostasis. Dysregulation of CES1 is linked to metabolic disorders, cardiovascular diseases, and neurotoxicity, making it a focus in pharmacology and disease research.
CES1 antibodies are used to detect and quantify CES1 protein levels in various biological samples, aiding in research on tissue-specific expression, enzymatic activity modulation, and disease mechanisms. Monoclonal antibodies offer high specificity for CES1 isoforms, while polyclonal antibodies may detect broader epitopes. Validation via knockout controls or enzymatic assays is essential to ensure antibody reliability.
Recent studies emphasize CES1's role in personalized medicine, particularly in predicting drug metabolism variability due to genetic polymorphisms. Additionally, its involvement in lipid signaling pathways highlights potential therapeutic targets for obesity and diabetes. CES1 antibodies also contribute to diagnostic development, as altered CES1 expression correlates with liver dysfunction and certain cancers. Ongoing research aims to refine antibody specificity and explore CES1's interplay with other metabolic enzymes, advancing its clinical and pharmacological relevance.
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