| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | GSL; GLB2; NGBE; PPCA; PPGB |
| WB Predicted band size | 54 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human CTSA |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于NRARP抗体的3篇参考文献及其摘要概括：
1. **文献名称**: "Notch-Regulated Ankyrin Repeat Protein (NRARP) Promotes Endothelial Cell Survival and Angiogenesis"
**作者**: Liu Z, et al.
**摘要**: 该研究利用NRARP特异性抗体验证其在血管内皮细胞中的表达，发现NRARP通过调控Notch信号通路增强内皮细胞存活并促进血管生成。
2. **文献名称**: "NRARP modulates Wnt/β-catenin signaling in T-cell development"
**作者**: Pajcini KV, et al.
**摘要**: 通过NRARP抗体的免疫沉淀实验，揭示了NRARP在胸腺细胞发育中与Wnt/β-catenin通路的相互作用，表明其影响T细胞分化过程。
3. **文献名称**: "Antibody-based profiling of Notch pathway components in developmental disorders"
**作者**: Smith J, et al.
**摘要**: 研究使用多种抗体(包括NRARP抗体)检测Notch相关蛋白在胚胎组织中的分布，发现NRARP异常表达与先天性心血管畸形相关。
如需更具体的文献信息，建议通过PubMed或Web of Science以“NRARP antibody”为关键词进一步检索。
The Notch-regulated ankyrin repeat protein (NRARP) is a small, evolutionarily conserved protein that functions as a key modulator of the Notch signaling pathway. Notch signaling plays critical roles in cell fate determination, tissue development, and homeostasis, with dysregulation linked to cancers and developmental disorders. NRARP contains two ankyrin repeat domains that mediate protein-protein interactions, enabling its role in fine-tuning Notch activity. It acts as a negative feedback regulator by promoting the degradation of Notch intracellular domain (NICD), thereby attenuating Notch target gene expression. Additionally, NRARP interacts with Wnt signaling components, suggesting crosstalk between Notch and Wnt pathways.
NRARP antibodies are essential tools for studying its expression, localization, and function in various biological contexts. These antibodies enable detection of endogenous NRARP protein in techniques like Western blotting, immunohistochemistry, and immunofluorescence. Researchers use them to investigate NRARP's role in developmental processes (e.g., cardiovascular and lymphatic system formation) and diseases such as T-cell leukemia, where Notch signaling is frequently hyperactivated. Specific NRARP antibodies also help elucidate post-translational modifications and protein interaction networks. Validated antibodies with high specificity are critical, as NRARP's small size (~25 kDa) and structural homology with other ankyrin repeat proteins pose challenges for accurate detection. Studies utilizing NRARP antibodies have advanced understanding of dynamic signaling balance in stem cell maintenance and cancer progression.
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