| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | MLC1SA |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human MYL6B |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于MYL6B抗体的3篇参考文献，按文献名称、作者及摘要内容整理如下：
1. **"Characterization of MYL6B in smooth muscle contraction and its role in vascular development"**
*作者：Li X, Zhang H, et al.*
摘要：本研究利用MYL6B特异性抗体，通过免疫荧光和Western blot技术，揭示了MYL6B在血管平滑肌细胞中的表达模式，并证明其通过调控肌球蛋白ATP酶活性参与血管张力维持及胚胎期血管发育。
2. **"A novel role of MYL6B in cancer cell migration via actin cytoskeleton remodeling"**
*作者：Wang Y, Chen J, et al.*
摘要：通过MYL6B抗体介导的蛋白质敲低实验，发现MYL6B在乳腺癌细胞中通过结合肌球蛋白重链调控细胞骨架重组，促进肿瘤细胞迁移，为癌症转移机制提供了新见解。
3. **"Tissue-specific expression and post-translational modification of MYL6B isoforms"**
*作者：Kuroda K, Tanaka T, et al.*
摘要：该研究开发了针对MYL6B不同磷酸化位点的抗体，系统分析了其在心肌、骨骼肌中的异构体表达差异，揭示了磷酸化修饰对MYL6B功能调控的关键作用。
注：以上文献为模拟示例，实际文献需通过PubMed、Google Scholar等平台检索确认。如需具体文章，建议结合抗体品牌(如Abcam、CST等)提供的引用文献或联系作者获取。
**Background of MYL6B Antibody**
The MYL6B (myosin light chain 6B) antibody is a tool used to detect and study the MYL6B protein, a component of the myosin light chain family. MYL6B, also known as MLC1SB, is a regulatory subunit of myosin VI, a motor protein involved in intracellular transport, cell motility, and membrane trafficking. Unlike other myosin light chains, MYL6B is specifically associated with myosin VI, which moves toward the minus end of actin filaments—a unique directionality among myosin motors.
MYL6B plays a critical role in modulating myosin VI’s mechanoenzymatic activity, ensuring proper cargo binding and actin-based movement. It is ubiquitously expressed but shows higher activity in tissues requiring dynamic cytoskeletal remodeling, such as the brain, kidneys, and testes. Dysregulation of MYL6B or myosin VI has been linked to pathologies, including neurodegenerative diseases, hearing loss, and cancer metastasis.
The MYL6B antibody is widely utilized in research to investigate protein localization, expression levels, and functional interactions in cellular models. It is validated for techniques like Western blotting, immunofluorescence, and immunoprecipitation. Recent studies emphasize its role in autophagy, endosomal sorting, and cell invasion, highlighting MYL6B as a potential biomarker or therapeutic target in diseases involving cytoskeletal dysfunction. Commercial MYL6B antibodies are typically raised in rabbits or mice, with specificity confirmed via knockout controls.
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