Rabbit Polyclonal PFDN1 Antibody

The PFDN1 antibody is a research tool designed to detect and study the Prefoldin subunit 1 (PFDN1), a component of the prefoldin chaperone complex. This hexameric complex, composed of six subunits (PFDN1-6), plays a critical role in protein folding by stabilizing nascent polypeptides and delivering them to the cytosolic chaperonin TCP-1 ring complex (TRiC) for proper folding. PFDN1. also known as prefoldin 1 or c-1. is ubiquitously expressed and involved in cellular processes such as cytoskeletal organization, gene regulation, and stress response. Dysregulation of PFDN1 has been implicated in neurodegenerative disorders, cancer, and developmental defects, making it a target for biomedical research. Antibodies against PFDN1 are widely used in techniques like Western blotting, immunofluorescence, and immunoprecipitation to analyze its expression, subcellular localization, and interactions. These antibodies are typically raised in hosts such as rabbits or mice, with validation steps including knockout/knockdown controls and specificity testing. Commercially available PFDN1 antibodies vary in clonality (monoclonal/polyclonal), epitope regions, and conjugates (e.g., HRP, fluorescent tags). Researchers utilize these tools to explore PFDN1's roles in diseases, its potential as a biomarker, and its interplay with other chaperone systems, contributing to understanding proteostasis mechanisms and therapeutic development.