Rabbit Polyclonal TDRD7 Antibody

The TDRD7 (Tudor domain-containing protein 7) antibody is a research tool designed to detect and study the TDRD7 protein, a key player in germ cell development and post-transcriptional gene regulation. TDRD7 belongs to the Tudor domain protein family, which interacts with arginine-methylated proteins, particularly those involved in piRNA (PIWI-interacting RNA) biogenesis and the formation of nuage granules in germ cells. It plays critical roles in spermatogenesis, oogenesis, and the maintenance of RNA stability. Dysregulation of TDRD7 has been linked to male infertility, cataracts, and certain cancers. The TDRD7 antibody enables researchers to investigate its expression patterns, subcellular localization (commonly observed in cytoplasmic granules), and interactions with partner molecules like MIWI and MILI proteins in piRNA pathways. Widely used in techniques such as Western blotting, immunohistochemistry, and immunofluorescence, this antibody helps elucidate molecular mechanisms underlying gametogenesis defects and RNA metabolism disorders. Commercial TDRD7 antibodies are typically raised in rabbits or mice against specific epitopes of the human or mouse protein, with validation in knockout models to confirm specificity. Ongoing studies focus on its dual roles in germline development and somatic tissues, particularly its association with cataracts through RNA granule dynamics in lens fiber cells.