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Rabbit Polyclonal INTS7 Antibody

  • 中文名: INTS7抗体
  • 别    名: INT7; C1orf73
货号: IPDX10603
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 1/5000-1/10000 Human,Mouse,Rat

产品详情

AliasesINT7; C1orf73
WB Predicted band size107 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenFusion protein of human INTS7
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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参考文献

以下是关于INTS7抗体的参考文献示例(注:部分文献信息为示例性质,建议通过学术数据库核实最新研究):

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1. **文献名称**: *"Integrator complex regulates NELF-mediated RNA polymerase II pause/release and processivity at coding genes"*

**作者**: Albrecht, T.R., et al.

**摘要**: 本研究揭示INTS7作为Integrator复合体亚基在RNA聚合酶II暂停和转录延伸调控中的作用,通过Western blot和免疫沉淀实验证实INTS7抗体用于检测其在基因启动子区域的招募机制。

2. **文献名称**: *"The Integrator complex in DNA repair and transcriptional regulation"*

**作者**: Skaar, J.R., et al.

**摘要**: 文章发现INTS7通过Integrator复合体参与DNA损伤修复通路,利用INTS7抗体进行免疫荧光实验,证明其与BRCA1蛋白的共定位,提示其在基因组稳定性中的功能。

3. **文献名称**: *"Subunit composition and substrate specificity of the human Integrator complex"*

**作者**: Gardini, A., et al.

**摘要**: 该研究系统分析Integrator复合体亚基的相互作用,通过INTS7抗体的免疫印迹和质谱分析,鉴定出INTS7与INTS3/INTS9形成的功能模块,调控小核RNA(snRNA)的加工。

4. **文献名称**: *"Integrator complex-dependent control of neurodevelopmental gene expression by NUDT21"*

**作者**: Li, W., et al.

**摘要**: 研究显示INTS7抗体用于检测神经发育模型中Integrator复合体的表达变化,发现其通过调控选择性多聚腺苷酸化影响神经元分化相关基因的表达。

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**注**:上述文献名称及内容为基于Integrator复合体相关研究的概括性示例,实际文献可能需要通过PubMed或Google Scholar以关键词“INTS7 antibody”或“Integrator complex subunit 7”进一步检索。

背景信息

The INTS7 antibody is designed to target the Integrator Complex Subunit 7 (INTS7), a component of the Integrator complex, a multi-protein assembly implicated in RNA polymerase II (RNAPII)-mediated transcription regulation. The Integrator complex, composed of at least 12 subunits (INTS1–12), plays dual roles in RNA processing and transcriptional regulation. Specifically, INTS7 is critical for the structural integrity and enzymatic activity of the complex, facilitating interactions with other subunits and RNAPII. It contributes to the cleavage of nascent RNAs, including small nuclear RNAs (snRNAs) and enhancer RNAs (eRNAs), and modulates transcriptional pausing or termination at specific loci. Dysregulation of INTS7 has been linked to developmental defects and cancers, underscoring its importance in gene expression control. The INTS7 antibody is widely used in molecular biology research to investigate its expression, localization, and function via techniques like Western blotting, immunoprecipitation, and immunofluorescence. It aids in elucidating mechanisms of transcriptional regulation, RNA processing, and disease pathogenesis. Commercial INTS7 antibodies are typically validated for specificity and sensitivity across human, mouse, or rat models, supporting studies in cancer biology, neurodevelopment, and epigenetic research.

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