Rabbit Polyclonal KPNA1 Antibody

KPNA1 (Karyopherin Alpha 1) is a member of the importin α family of nuclear transport proteins that mediate nucleocytoplasmic transport by shuttling cargo proteins containing nuclear localization signals (NLS) into the nucleus. It plays a critical role in regulating cellular processes such as gene expression, signal transduction, and immune responses by facilitating the nuclear import of transcription factors, cell cycle regulators, and viral proteins. KPNA1 antibodies are essential tools for studying its expression, localization, and interactions in various biological contexts. These antibodies are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to detect KPNA1 in cell or tissue samples. Research involving KPNA1 antibodies has shed light on its dysregulation in diseases, including cancer (e.g., altered expression in breast, lung, and colorectal cancers), neurodegenerative disorders, and viral infections. Specificity and validation of KPNA1 antibodies are crucial due to high homology among importin α family members. Recent studies also explore its role in cellular stress responses and as a potential therapeutic target. Proper antibody selection ensures accurate detection of KPNA1's distinct isoforms and post-translational modifications, which influence its function in health and disease.