| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/300 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | CAN19; S100L |
| WB Predicted band size | 11 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein of human S100A2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇关于S100A2抗体的代表性文献及其摘要概括：
1. **文献名称**: "S100A2 is a prognostic biomarker involved in immune infiltration and correlates with chemotherapy response in breast cancer"
**作者**: Li, X., et al.
**摘要**: 该研究利用免疫组化(使用S100A2抗体)分析乳腺癌组织中S100A2的表达，发现其高表达与不良预后相关，并提示S100A2可能通过调节肿瘤微环境中的免疫细胞浸润影响化疗敏感性。
2. **文献名称**: "S100A2 suppresses metastasis and resistance to anticancer drugs in non-small cell lung cancer"
**作者**: Tanaka, M., et al.
**摘要**: 通过Western blot和免疫荧光(采用S100A2特异性抗体)，研究发现S100A2在肺癌中低表达，其缺失促进肿瘤转移和耐药性，提示S100A2可能作为抑制肿瘤进展的潜在靶点。
3. **文献名称**: "S100A2 protein is a sensitive marker for squamous cell carcinoma of the bladder"
**作者**: Wang, H., et al.
**摘要**: 研究通过免疫组化(使用S100A2单克隆抗体)发现，膀胱鳞状细胞癌中S100A2表达显著上调，表明该抗体可作为区分膀胱鳞癌与其他亚型的高特异性诊断工具。
注：以上文献为示例性内容，实际引用时建议通过PubMed或Web of Science核对最新研究。
The S100A2 antibody is a crucial tool for studying the S100A2 protein, a member of the S100 calcium-binding protein family. S100A2 is implicated in regulating cellular processes such as cell cycle progression, differentiation, and cytoskeletal dynamics. Unlike other S100 proteins, S100A2 exhibits tissue-specific expression, predominantly in epithelial cells, and has dual roles in cancer, acting as either a tumor suppressor or promoter depending on the cancer type. For example, it is downregulated in prostate and breast cancers but overexpressed in lung and pancreatic cancers, highlighting its context-dependent functions.
S100A2 antibodies are widely used in techniques like immunohistochemistry (IHC), Western blotting (WB), and immunofluorescence (IF) to detect protein expression, localization, and interactions. These antibodies are typically raised in hosts such as rabbits or mice, with specificity validated via knockout controls or siRNA silencing. Commercial S100A2 antibodies often target conserved epitopes, ensuring cross-reactivity across species like human, mouse, and rat.
Research leveraging S100A2 antibodies has advanced understanding of its role in cancer prognosis, metastasis, and therapeutic targeting. Additionally, studies explore its involvement in inflammatory diseases and wound healing. However, variability in antibody performance across experimental conditions necessitates careful validation. Overall, S100A2 antibodies remain pivotal in elucidating the protein's diverse biological and pathological mechanisms.
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