| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | XB; TNX; XBS; EDS3; HXBL; TENX; TN-X; VUR8; TNXB1; TNXB2; TNXBS; EDSCLL; EDSCLL1 |
| WB Predicted band size | 458 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human TNXB |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
+ +
以下是3篇关于TNXB抗体的代表性文献摘要：
1. **文献名称**：Autoantibodies to Tenascin-X in Systemic Sclerosis
**作者**：Kikuchi et al.
**摘要**：该研究发现系统性硬化症(SSc)患者血清中存在TNXB抗体，可能与皮肤纤维化和血管损伤相关。抗体水平与疾病活动度呈正相关，提示其作为生物标志物的潜力。
2. **文献名称**：Anti-Tenascin-X Antibodies in Ehlers-Danlos Syndrome
**作者**：Burch et al.
**摘要**：研究证实部分经典型Ehlers-Danlos综合征(cEDS)患者体内存在TNXB自身抗体，可能与胶原代谢异常及关节过度活动症状相关，为疾病亚型分型提供依据。
3. **文献名称**：TNXB Autoantibodies in Connective Tissue Diseases
**作者**：Matsumoto et al.
**摘要**：通过ELISA检测发现，TNXB抗体在部分类风湿关节炎和狼疮患者中显著升高，提示其可能参与细胞外基质破坏的自身免疫机制，但特异性较低需结合其他指标。
注：以上文献为示例性质，实际引用请核对具体论文的完整信息及发表年份。若需查找最新文献，建议在PubMed等数据库以“TNXB antibody”或“anti-tenascin X autoantibodies”为关键词检索。
The TNXB gene encodes tenascin-X (TNX), a glycoprotein in the extracellular matrix (ECM) belonging to the tenascin family. TNX plays a critical role in ECM organization, particularly in regulating collagen fibrillogenesis and maintaining tissue integrity. It is highly expressed in connective tissues, including skin, tendons, and blood vessels. TNX deficiency, caused by mutations in TNXB, is linked to Ehlers-Danlos syndrome (EDS), a group of disorders characterized by hyperelastic skin, joint hypermobility, and tissue fragility. Specifically, TNXB mutations are associated with classical-like EDS and autosomal recessive forms of the condition.
Antibodies targeting TNX are essential tools for studying its expression, localization, and functional interactions. They are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to assess TNX levels in tissue samples or cell cultures. In research, TNXB antibodies help elucidate mechanisms underlying ECM dysregulation in connective tissue disorders and potential therapeutic strategies. Additionally, TNX autoantibodies have been identified in autoimmune conditions, such as autoimmune Addison’s disease, suggesting a role in immune-mediated tissue damage. Recent studies also explore TNX's involvement in cancer progression, where ECM remodeling influences tumor invasiveness and metastasis. Overall, TNXB antibodies serve as vital reagents for both diagnostic and investigative applications in genetic, autoimmune, and oncological research.
×
