| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/300 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human TSR1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于TSR1抗体的3篇代表性文献的简要总结(注：以下内容为基于领域知识的假设性示例，实际文献需通过学术数据库查询)：
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1. **文献名称**：*TSR1 is essential for 18S rRNA maturation and ribosome assembly in Saccharomyces cerevisiae*
**作者**：Smith A, et al.
**摘要**：该研究通过构建TSR1基因敲除的酵母模型，结合TSR1抗体的免疫印迹和免疫荧光技术，发现TSR1定位于核仁，并参与18S rRNA的剪切过程，其缺失导致核糖体亚基组装缺陷，细胞生长停滞。
2. **文献名称**：*TSR1 overexpression promotes tumorigenesis by dysregulating ribosome biogenesis in colorectal cancer*
**作者**：Li X, et al.
**摘要**：利用TSR1抗体进行免疫组织化学分析，研究发现TSR1在结直肠癌组织中显著高表达，并与患者不良预后相关。体外实验表明TSR1通过调控rRNA加工促进癌细胞增殖和侵袭。
3. **文献名称**：*Structural and functional characterization of human TSR1 in ribosome biogenesis*
**作者**：Müller B, et al.
**摘要**：通过TSR1抗体介导的免疫共沉淀和质谱分析，揭示了TSR1与核糖体组装因子Utp23和Rrp7的相互作用，证实其在人类细胞中协调核糖体小亚基成熟的分子机制。
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如需具体文献，建议通过PubMed或Google Scholar搜索关键词“TSR1 antibody”、“TSR1 ribosome”获取最新研究。
TSR1 (Transportin-SR2), also known as Transportin-3 or TNPO3. is a nuclear transport receptor belonging to the importin-β family. It facilitates the nuclear import of specific cargo proteins, particularly those involved in mRNA processing and splicing, such as serine/arginine-rich (SR) proteins. TSR1 recognizes cargoes via their phosphorylated RS (arginine-serine) domains, playing a critical role in regulating gene expression and RNA metabolism. Dysregulation of TSR1 has been implicated in diseases like cancer, viral infections, and neurodegenerative disorders.
Antibodies targeting TSR1 are essential tools for studying its expression, localization, and functional interactions. They are widely used in techniques like Western blotting, immunofluorescence, and immunoprecipitation to investigate TSR1's role in cellular processes. For instance, studies utilizing TSR1 antibodies have revealed its involvement in HIV-1 replication, where it mediates nuclear import of viral integrase. In cancer research, these antibodies help explore TSR1's association with splicing dysregulation and tumor progression. Additionally, TSR1 antibodies contribute to understanding its interactions with disease-linked proteins, such as FUS in amyotrophic lateral sclerosis (ALS). Commercial TSR1 antibodies are typically validated for specificity across human and model organisms, supporting both basic and translational research.
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