Rabbit Polyclonal ZDHHC5 Antibody

ZDHHC5 antibody is a research tool designed to target the ZDHHC5 protein, a member of the DHHC (Asp-His-His-Cys) palmitoyltransferase family. These enzymes catalyze protein palmitoylation, a post-translational modification critical for membrane anchoring, protein trafficking, and signal transduction. ZDHHC5. specifically, is a transmembrane protein localized to the plasma membrane and Golgi apparatus. It mediates S-palmitoylation of substrate proteins, influencing their stability, localization, and interactions. Studies have linked ZDHHC5 to diverse cellular processes, including cell adhesion, migration, and synaptic plasticity. Its dysregulation has been implicated in cancer progression, neurological disorders, and viral infections (e.g., influenza A virus entry). The ZDHHC5 antibody is widely used in techniques like Western blotting, immunofluorescence, and immunoprecipitation to detect endogenous ZDHHC5 expression, study its subcellular distribution, and investigate its molecular interactions. Commercial antibodies are typically validated for specificity against human, mouse, or rat samples. Recent research highlights its role in regulating membrane receptor signaling (e.g., EGFR) and tumor microenvironment remodeling. However, functional redundancy within the DHHC family and ZDHHC5's auto-palmitoylation activity pose challenges in experimental interpretation, necessitating rigorous antibody validation and complementary genetic approaches.