Rabbit Polyclonal ZNF184 Antibody

The ZNF184 antibody is designed to detect Zinc Finger Protein 184 (ZNF184), a member of the zinc finger protein family involved in transcriptional regulation. Zinc finger proteins, characterized by conserved C2H2-type zinc finger domains, typically bind DNA or RNA to modulate gene expression. ZNF184 is primarily expressed in the testis and has been linked to spermatogenesis, with studies suggesting its role in male infertility when dysregulated. Additionally, ZNF184 has been implicated in cancer biology. Research shows altered expression in prostate cancer, where overexpression may correlate with tumor progression, and in colorectal cancer, where promoter hypermethylation of ZNF184 is associated with transcriptional silencing, potentially serving as a diagnostic biomarker. The ZNF184 antibody is utilized in techniques like Western blotting, immunohistochemistry, and immunofluorescence to study its expression patterns, cellular localization, and interactions in disease contexts. These studies aim to clarify ZNF184's functional mechanisms, such as its influence on cell proliferation, apoptosis, or metastasis. While current findings highlight its potential as a therapeutic target or diagnostic tool, further validation is needed to establish its clinical relevance. The antibody thus serves as a critical reagent for exploring ZNF184's biological roles and pathological contributions across different tissues and diseases.