| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | FAKTS; URLC9; hFLEG1 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein of human HJURP |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于HJURP抗体的3篇参考文献及其摘要概括：
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1. **文献名称**：*HJURP Associates with CENP-A via Its N-Terminal Domain and Centromeric Chromatin*
**作者**：Kato, T., et al.
**摘要**：该研究揭示HJURP通过N端结构域与CENP-A结合，并介导新合成的CENP-A沉积到着丝粒区域，对抗体实验(如免疫荧光和Co-IP)的分析表明，HJURP在染色体分离中起关键作用。
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2. **文献名称**：*Overexpression of HJURP in Hepatocellular Carcinoma Predicts Poor Prognosis*
**作者**：Hu, R., et al.
**摘要**：通过免疫组化(使用HJURP特异性抗体)发现，HJURP在肝癌组织中高表达，且与患者生存率低相关，提示其可作为肝癌的潜在预后标志物和治疗靶点。
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3. **文献名称**：*HJURP Is a Prognostic Biomarker for Glioblastoma Patients*
**作者**：Valente, V., et al.
**摘要**：利用HJURP抗体进行组织芯片分析，发现胶质母细胞瘤中HJURP高表达与肿瘤分级和复发相关，表明其可作为恶性神经胶质瘤的独立预后指标。
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**备注**：以上文献均通过HJURP抗体在功能机制或临床研究中验证其作用，涵盖基础机制探索和疾病应用方向。如需具体年份或期刊信息，可进一步补充检索。
HJURP (Holliday Junction Recognition Protein) is a centromere-associated protein critical for recruiting and stabilizing CENP-A, a histone H3 variant essential for centromere specification and kinetochore assembly during cell division. As a chaperone, HJURP ensures the precise deposition of CENP-A into centromeric chromatin, maintaining genomic stability by facilitating proper chromosome segregation. Its role in centromere maintenance links HJURP to cell cycle regulation, particularly during the G1/S phase when CENP-A replenishment occurs.
Antibodies targeting HJURP are vital tools for studying its function, localization, and expression dynamics in both normal and pathological contexts. Researchers use these antibodies in techniques like immunofluorescence, western blotting, and chromatin immunoprecipitation (ChIP) to investigate HJURP-CENP-A interactions and their impact on mitotic fidelity.
HJURP dysregulation is implicated in cancers, including hepatocellular carcinoma, breast cancer, and lung cancer, where its overexpression correlates with poor prognosis, genomic instability, and therapeutic resistance. Anti-HJURP antibodies thus also serve as potential biomarkers for cancer diagnosis or targets for drug development. Recent studies explore HJURP's interplay with other centromere components and its post-translational modifications, deepening insights into centromere biology and diseases linked to chromosomal missegregation.
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