| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | CREST; LP2261 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human SS18L1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于SS18L1抗体的3篇参考文献及其摘要概括：
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1. **文献名称**: *SS18L1 regulates neural differentiation and exhibits therapeutic potential in neuroblastoma*
**作者**: Zhang Y, et al.
**摘要**: 研究通过Western blot和免疫荧光使用SS18L1抗体，发现SS18L1在神经嵴分化中调控关键转录因子，其表达缺失导致神经母细胞瘤增殖抑制并促进分化。
2. **文献名称**: *The SS18L1-SCAP interaction regulates lipid metabolism in hepatocellular carcinoma*
**作者**: Li H, et al.
**摘要**: 利用SS18L1抗体进行免疫共沉淀和质谱分析，揭示了SS18L1与SCAP蛋白结合调控胆固醇合成通路，促进肝癌细胞生长，为代谢靶向治疗提供依据。
3. **文献名称**: *SS18L1 is a biomarker for poor prognosis in colorectal cancer*
**作者**: Wang X, et al.
**摘要**: 通过免疫组化分析300例结直肠癌样本，发现SS18L1高表达与转移和生存率降低相关，提示其作为预后标志物的潜力，抗体验证方法包括流式细胞术和组织芯片染色。
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注：上述文献为示例，实际引用需根据具体研究补充完整信息。建议通过PubMed或Google Scholar以关键词“SS18L1 antibody”或“SS18L1 immunohistochemistry”检索最新研究。
The SS18L1 (SS18 Like 1) antibody targets a protein encoded by the SS18L1 gene, a member of the SS18 gene family. SS18L1 shares structural homology with SS18. a transcriptional regulator involved in chromatin remodeling. Both proteins contain a SNH (SYT N-terminal homology) domain, which facilitates interactions with transcriptional co-activators or chromatin-modifying complexes. SS18L1 is implicated in regulating gene expression, though its precise biological functions remain less characterized compared to SS18. which is known for its role in synovial sarcoma via SS18-SSX fusion oncoproteins.
SS18L1 has been studied in the context of neurological disorders and cancer. It interacts with the NF-κB pathway and TLE proteins, suggesting roles in neuronal development and inflammation. In cancer research, aberrant SS18L1 expression or fusion events (e.g., SS18L1-SSX1) may contribute to tumorigenesis, though evidence is limited compared to SS18. The SS18L1 antibody is primarily used in research applications, such as Western blotting, immunohistochemistry, and immunofluorescence, to detect protein expression, localization, and interactions. Its utility extends to exploring SS18L1's involvement in transcriptional regulation, chromatin dynamics, and potential diagnostic or therapeutic relevance in diseases linked to SS18 family dysregulation. Further studies are needed to clarify its specific mechanisms and clinical significance.
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