Rabbit Polyclonal COPS6 Antibody

The COPS6 antibody is a research tool targeting the COP9 signalosome subunit 6 (COPS6), also known as CSN6. a component of the evolutionarily conserved COP9 signalosome (CSN) complex. The CSN complex, comprising eight subunits (CSN1–CSN8), regulates ubiquitin-proteasome-mediated protein degradation by modulating cullin-RING ubiquitin ligases (CRLs) through deneddylation. COPS6 plays a critical role in maintaining the structural integrity of the CSN complex and fine-tuning substrate specificity during protein turnover. It is implicated in diverse cellular processes, including cell cycle progression, DNA damage response, and apoptosis. Dysregulation of COPS6 has been linked to cancer, where its overexpression promotes tumorigenesis by stabilizing oncoproteins or destabilizing tumor suppressors. Additionally, COPS6 interacts with signaling pathways such as NF-κB and p53. influencing inflammation and stress responses. Antibodies against COPS6 are widely used in molecular biology to study its expression, localization, and function via techniques like Western blotting, immunoprecipitation, and immunofluorescence. They also aid in exploring COPS6's role in diseases, particularly its potential as a therapeutic target. Research using COPS6 antibodies has advanced understanding of post-translational regulation and its implications in cellular homeostasis and pathology.